IMAGE cDNA克隆、基因簇及ACeDB：表达序列信息的整合资源。
IMAGE cDNA clones, UniGene clustering, and ACeDB: an integrated resource for expressed sequence information.
作者信息
Miller G, Fuchs R, Lai E
机构信息
Department of Bioinformatics, Glaxo Wellcome Research and Development, Research Triangle Park, North Carolina 27709, USA.
出版信息
Genome Res. 1997 Oct;7(10):1027-32. doi: 10.1101/gr.7.10.1027.
Abstract
In this study we describe a new information resource that provides integrated access to information on IMAGE (integrated molecular analysis of genomes and their expression) cDNA library clones and derived expressed sequence tags (ESTs). We have developed an automated procedure that collates data from various public sources into a single ACeDB database. This database is a valuable tool for electronic cloning experiments and gene expression studies. It allows researchers to find information about cDNA libraries, plate addresses, insert sizes, and sequence data for IMAGE clones, the assignment of ESTs to UniGene clusters, and the chromosomal location of those genes in an efficient, graphically oriented manner.
摘要
在本研究中，我们描述了一种新的信息资源，它提供对IMAGE（基因组及其表达的综合分子分析）cDNA文库克隆和衍生的表达序列标签（EST）信息的集成访问。我们开发了一种自动化程序，可将来自各种公共来源的数据整理到一个ACeDB数据库中。该数据库是电子克隆实验和基因表达研究的宝贵工具。它使研究人员能够以高效、图形化的方式查找有关cDNA文库、平板地址、插入片段大小和IMAGE克隆的序列数据、EST在UniGene簇中的分配以及这些基因的染色体定位等信息。
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