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本文引用的文献

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SGD: Saccharomyces Genome Database.SGD：酿酒酵母基因组数据库。
Nucleic Acids Res. 1998 Jan 1;26(1):73-9. doi: 10.1093/nar/26.1.73.
2
Analysis of the functional role of conserved residues in the protein subunit of ribonuclease P from Escherichia coli.大肠杆菌核糖核酸酶P蛋白亚基中保守残基的功能作用分析。
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A novel protein shared by RNase MRP and RNase P.一种核糖核酸酶MRP和核糖核酸酶P共有的新型蛋白质。
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Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P.两种与人类核糖核酸酶P共纯化的硬皮病自身免疫抗原的特性分析。
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Pop3p is essential for the activity of the RNase MRP and RNase P ribonucleoproteins in vivo.Pop3p对于核糖核酸酶MRP和核糖核酸酶P核糖核蛋白在体内的活性至关重要。
EMBO J. 1997 Jan 15;16(2):417-29. doi: 10.1093/emboj/16.2.417.
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The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae.外排体是酿酒酵母中胞吐作用所需的一种多蛋白复合体。
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7
RRP5 is required for formation of both 18S and 5.8S rRNA in yeast.RRP5是酵母中18S和5.8S rRNA形成所必需的。
EMBO J. 1996 Oct 15;15(20):5701-14.
8
Association of RNase mitochondrial RNA processing enzyme with ribonuclease P in higher ordered structures in the nucleolus: a possible coordinate role in ribosome biogenesis.核糖核酸酶线粒体RNA加工酶与核仁中更高层次结构的核糖核酸酶P的关联：在核糖体生物发生中可能的协同作用。
Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11471-6. doi: 10.1073/pnas.93.21.11471.
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Life with 6000 genes.拥有6000个基因的生命。
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10
Processing of the yeast pre-rRNA at sites A(2) and A(3) is linked.酵母前体rRNA在A(2)和A(3)位点的加工是相关联的。
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Rpp1是酿酒酵母中前体tRNA和35S前体rRNA加工所需的核核糖核酸酶P的必需蛋白质亚基。

Rpp1, an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA in Saccharomyces cerevisiae.

作者信息

Stolc V, Altman S

机构信息

Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

出版信息

Genes Dev. 1997 Nov 1;11(21):2926-37. doi: 10.1101/gad.11.21.2926.

DOI:10.1101/gad.11.21.2926
PMID:9353260
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC316654/
Abstract

The gene for an essential protein subunit of nuclear RNase P from Saccharomyces cerevisiae has been cloned. The gene for this protein, RPP1, was identified by virtue of its homology with a human scleroderma autoimmune antigen, Rpp30, which copurifies with human RNase P. Epitope-tagged Rpp1 can be found in association with both RNase P RNA and a related endoribonuclease, RNase MRP RNA, in immunoprecipitates from crude extracts of cells. Depletion of Rpp1 in vivo leads to the accumulation of precursor tRNAs with unprocessed 5' and 3' termini and reveals rRNA processing defects that have not been described previously for proteins associated with RNase P or RNase MRP. Immunoprecipitated complexes cleave both yeast precursor tRNAs and precursor rRNAs.

摘要

酿酒酵母核核糖核酸酶P的一种必需蛋白质亚基的基因已被克隆。该蛋白质的基因RPP1是通过与人类硬皮病自身免疫抗原Rpp30的同源性鉴定出来的，Rpp30与人类核糖核酸酶P共纯化。在细胞粗提物的免疫沉淀中，可发现表位标记的Rpp1与核糖核酸酶P RNA和一种相关的核糖核酸内切酶核糖核酸酶MRP RNA结合。体内Rpp1的缺失会导致5'和3'末端未加工的前体tRNA积累，并揭示了与核糖核酸酶P或核糖核酸酶MRP相关的蛋白质以前未描述过的rRNA加工缺陷。免疫沉淀复合物可切割酵母前体tRNA和前体rRNA。