树突状细胞的个体发生：源自髓系的人类树突状细胞谱系。
Dendritic cell ontogeny: a human dendritic cell lineage of myeloid origin.
作者信息
Olweus J, BitMansour A, Warnke R, Thompson P A, Carballido J, Picker L J, Lund-Johansen F
机构信息
Becton Dickinson Immunocytometry Systems, 2350 Qume Drive, San Jose, CA 95131, USA.
出版信息
Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12551-6. doi: 10.1073/pnas.94.23.12551.
Dendritic cells (DC) have been thought to represent a family of closely related cells with similar functions and developmental pathways. The best-characterized precursors are the epidermal Langerhans cells, which migrate to lymphoid organs and become activated DC in response to inflammatory stimuli. Here, we demonstrate that a large subset of DC in the T cell-dependent areas of human lymphoid organs are nonactivated cells and belong to a separate lineage that can be identified by high levels of the interleukin 3 receptor alpha chain (IL-3Ralphahi). The CD34+IL-3Ralphahi DC progenitors are of myeloid origin and are distinct from those that give rise to Langerhans cells in vitro. The IL-3Ralphahi DC furthermore appear to migrate to lymphoid organs independently of inflammatory stimuli or foreign antigens. Thus, DC are heterogeneous with regard to function and ontogeny.
树突状细胞（DC）被认为是一类功能和发育途径相似的密切相关细胞家族。特征最明确的前体细胞是表皮朗格汉斯细胞，其迁移至淋巴器官并在炎症刺激下成为活化的DC。在此，我们证明人类淋巴器官中T细胞依赖区的大部分DC是非活化细胞，属于一个可通过高水平白细胞介素3受体α链（IL-3Rα高表达）识别的独立谱系。CD34 + IL-3Rα高表达的DC祖细胞起源于髓系，与体外产生朗格汉斯细胞的祖细胞不同。此外，IL-3Rα高表达的DC似乎独立于炎症刺激或外来抗原迁移至淋巴器官。因此，DC在功能和个体发生方面是异质性的。
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