视觉识别过程中梨状周围皮质内毒蕈碱阻断的作用
Effects of muscarinic blockade in perirhinal cortex during visual recognition.
作者信息
Tang Y, Mishkin M, Aigner T G
机构信息
Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD 20892-4415, USA.
出版信息
Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12667-9. doi: 10.1073/pnas.94.23.12667.
Abstract
Stimulus recognition in monkeys is severely impaired by destruction or dysfunction of the perirhinal cortex and also by systemic administration of the cholinergic-muscarinic receptor blocker, scopolamine. These two effects are shown here to be linked: Stimulus recognition was found to be significantly impaired after bilateral microinjection of scopolamine directly into the perirhinal cortex, but not after equivalent injections into the laterally adjacent visual area TE or into the dentate gyrus of the overlying hippocampal formation. The results suggest that the formation of stimulus memories depends critically on cholinergic-muscarinic activation of the perirhinal area, providing a new clue to how stimulus representations are stored.
摘要
对猴子而言，鼻周皮质的破坏或功能障碍以及全身性给予胆碱能毒蕈碱受体阻滞剂东莨菪碱会严重损害刺激识别能力。本文表明这两种效应存在关联：研究发现，将东莨菪碱双侧微量注射到鼻周皮质后，刺激识别能力会显著受损，但等量注射到相邻的外侧视觉区域TE或上方海马结构的齿状回后则不会。这些结果表明，刺激记忆的形成关键取决于鼻周区域的胆碱能毒蕈碱激活，这为刺激表征的存储方式提供了新线索。
相似文献
1
Effects of muscarinic blockade in perirhinal cortex during visual recognition.视觉识别过程中梨状周围皮质内毒蕈碱阻断的作用
Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12667-9. doi: 10.1073/pnas.94.23.12667.
2
Differential effects of m1 and m2 receptor antagonists in perirhinal cortex on visual recognition memory in monkeys.杏仁周皮质 m1 和 m2 受体拮抗剂对猴子视觉识别记忆的差异影响。
Neurobiol Learn Mem. 2012 Jul;98(1):41-6. doi: 10.1016/j.nlm.2012.04.007. Epub 2012 Apr 26.
3
Muscarinic receptors activity in the perirhinal cortex and hippocampus has differential involvement in the formation of recognition memory.毒蕈碱型乙酰胆碱受体在边缘皮层和海马中的活性对识别记忆的形成有不同的参与作用。
Neurobiol Learn Mem. 2012 May;97(4):418-24. doi: 10.1016/j.nlm.2012.03.006. Epub 2012 Mar 20.
4
Perirhinal cortex muscarinic receptor blockade impairs taste recognition memory formation.梨状皮质毒蕈碱受体阻断会损害味觉识别记忆的形成。
Learn Mem. 2004 Jan-Feb;11(1):95-101. doi: 10.1101/lm.69704.
5
Cholinergic neurotransmission is essential for perirhinal cortical plasticity and recognition memory.胆碱能神经传递对于嗅周皮质可塑性和识别记忆至关重要。
Neuron. 2003 Jun 19;38(6):987-96. doi: 10.1016/s0896-6273(03)00358-1.
6
Paradoxical facilitation of object recognition memory after infusion of scopolamine into perirhinal cortex: implications for cholinergic system function.将东莨菪碱注入嗅周皮质后对物体识别记忆的反常促进作用：对胆碱能系统功能的启示
J Neurosci. 2006 Sep 13;26(37):9520-9. doi: 10.1523/JNEUROSCI.2319-06.2006.
7
Critical role of the cholinergic system for object-in-place associative recognition memory.胆碱能系统在物体位置联想识别记忆中的关键作用。
Learn Mem. 2008 Dec 30;16(1):8-11. doi: 10.1101/lm.1121309. Print 2009 Jan.
8
Muscimol, AP5, or scopolamine infused into perirhinal cortex impairs two-choice visual discrimination learning in rats.麦司卡林、AP5 或东莨菪碱注入侧眶回皮层会损害大鼠的二选一视觉辨别学习能力。
Neurobiol Learn Mem. 2010 Feb;93(2):221-8. doi: 10.1016/j.nlm.2009.10.002. Epub 2009 Oct 13.
9
Differing time dependencies of object recognition memory impairments produced by nicotinic and muscarinic cholinergic antagonism in perirhinal cortex.不同时间依赖性的客体识别记忆损伤由烟碱型和毒蕈碱型乙酰胆碱能拮抗作用在边缘皮层产生。
Learn Mem. 2011 Jun 21;18(7):484-92. doi: 10.1101/lm.2274911. Print 2011.
10
Estrous cycle stage gates sex differences in prefrontal muscarinic control of fear memory formation.发情周期阶段控制前额叶烟碱型乙酰胆碱受体对恐惧记忆形成的性别差异。
Neurobiol Learn Mem. 2019 May;161:26-36. doi: 10.1016/j.nlm.2019.03.001. Epub 2019 Mar 6.
引用本文的文献
1
Cholinergic blockade reveals role for human hippocampal theta in encoding but not retrieval.胆碱能阻断揭示了人类海马θ波在编码而非检索过程中的作用。
bioRxiv. 2025 May 12:2025.05.12.653487. doi: 10.1101/2025.05.12.653487.
2
Brain areas interconnected to ventral pathway circuits are independently able to induce enhancement in object recognition memory and cause reversal in object recognition memory deficit.与腹侧通路回路相互连接的脑区能够独立诱导物体识别记忆增强，并使物体识别记忆缺陷发生逆转。
CNS Neurosci Ther. 2024 Apr;30(4):e14727. doi: 10.1111/cns.14727.
3
Acetylcholine modulates the temporal dynamics of human theta oscillations during memory.乙酰胆碱调节记忆过程中人类θ振荡的时间动态。
Nat Commun. 2023 Aug 30;14(1):5283. doi: 10.1038/s41467-023-41025-y.
4
Neonicotinoid Imidacloprid Affects the Social Behavior of Adult Zebrafish by Damaging Telencephalon Neurons through Oxidation Stress, Inflammation, and Apoptosis.新烟碱类杀虫剂吡虫啉通过氧化应激、炎症和细胞凋亡损伤端脑神经元，影响成年斑马鱼的社会行为。
Life (Basel). 2023 Jun 20;13(6):1418. doi: 10.3390/life13061418.
5
Intrahippocampal blockade of nicotinic or muscarinic receptors fails to impair nonnavigational spatial memory in macaques.内侧海马体烟碱型或毒蕈碱型受体阻断未能损害猕猴的非航行空间记忆。
Behav Neurosci. 2021 Aug;135(4):581-590. doi: 10.1037/bne0000444. Epub 2021 Feb 25.
6
Activation of cortical M muscarinic receptors and related intracellular signaling is necessary for reactivation-induced object memory updating.皮质 M 毒蕈碱受体的激活和相关的细胞内信号转导对于再激活诱导的物体记忆更新是必要的。
Sci Rep. 2020 Jun 8;10(1):9209. doi: 10.1038/s41598-020-65836-x.
7
Differential responsivity of neurons in perirhinal cortex, lateral entorhinal cortex, and dentate gyrus during time-bridging learning.在时间桥接学习过程中，边缘皮层、外侧内嗅皮层和齿状回神经元的反应差异。
Hippocampus. 2019 Jun;29(6):511-526. doi: 10.1002/hipo.23041. Epub 2018 Nov 25.
8
Topographic organization of the basal forebrain projections to the perirhinal, postrhinal, and entorhinal cortex in rats.大鼠基底前脑向梨状周皮质、嗅周皮质和内嗅皮质投射的拓扑组织
J Comp Neurol. 2016 Aug 15;524(12):2503-15. doi: 10.1002/cne.23967. Epub 2016 Feb 17.
9
The challenge of understanding the brain: where we stand in 2015.理解大脑的挑战：2015年我们所处的位置。
Neuron. 2015 May 20;86(4):864-882. doi: 10.1016/j.neuron.2015.03.032.
10
Blockade of glutamatergic transmission in perirhinal cortex impairs object recognition memory in macaques.阻断猕猴嗅周皮质中的谷氨酸能传递会损害其物体识别记忆。
J Neurosci. 2015 Mar 25;35(12):5043-50. doi: 10.1523/JNEUROSCI.4307-14.2015.
本文引用的文献
1
Functional double dissociation between two inferior temporal cortical areas: perirhinal cortex versus middle temporal gyrus.颞下回两个区域之间的功能双重分离：嗅周皮层与颞中回。
J Neurophysiol. 1997 Feb;77(2):587-98. doi: 10.1152/jn.1997.77.2.587.
2
Release of cerebral acetylcholine increases during visually mediated behavior in monkeys.
Neuroreport. 1996 Sep 2;7(13):2231-5. doi: 10.1097/00001756-199609020-00034.
3
Cholinergic-glutamatergic interactions in visual recognition memory of rhesus monkeys.恒河猴视觉识别记忆中的胆碱能-谷氨酸能相互作用
Neuroreport. 1996 Jan 31;7(2):565-8. doi: 10.1097/00001756-199601310-00045.
4
Lesions of the perirhinal and parahippocampal cortices in the monkey produce long-lasting memory impairment in the visual and tactual modalities.猴子的嗅周皮质和海马旁皮质损伤会在视觉和触觉模式下产生持久的记忆障碍。
J Neurosci. 1993 Jun;13(6):2430-51. doi: 10.1523/JNEUROSCI.13-06-02430.1993.
5
Activity of neurons in anterior inferior temporal cortex during a short-term memory task.短期记忆任务期间颞下回前部神经元的活动。
J Neurosci. 1993 Apr;13(4):1460-78. doi: 10.1523/JNEUROSCI.13-04-01460.1993.
6
Scopolamine affects short-term memory but not inferior temporal neurons.
Neuroreport. 1993 Jan;4(1):81-4. doi: 10.1097/00001756-199301000-00021.
7
The representation of stimulus familiarity in anterior inferior temporal cortex.前颞下回皮质中刺激熟悉度的表征。
J Neurophysiol. 1993 Jun;69(6):1918-29. doi: 10.1152/jn.1993.69.6.1918.
8
MK-801 impairs recognition memory in rhesus monkeys: comparison with cholinergic drugs.MK-801损害恒河猴的识别记忆：与胆碱能药物的比较。
J Pharmacol Exp Ther. 1993 Jul;266(1):60-4.
9
Neuronal activity related to visual recognition memory: long-term memory and the encoding of recency and familiarity information in the primate anterior and medial inferior temporal and rhinal cortex.与视觉识别记忆相关的神经元活动：灵长类动物前颞叶和内侧颞下回及鼻周皮质中的长期记忆以及近期性和熟悉度信息的编码
Exp Brain Res. 1993;96(3):457-72. doi: 10.1007/BF00234113.
10
Effects on visual recognition of combined and separate ablations of the entorhinal and perirhinal cortex in rhesus monkeys.猕猴内嗅皮层和嗅周皮层联合及单独切除对视觉识别的影响。
J Neurosci. 1993 Dec;13(12):5418-32. doi: 10.1523/JNEUROSCI.13-12-05418.1993.
Zotero 插件