Orr W C, Crowell M D, Lin B, Harnish M J, Chen J D
Thomas N. Lynn Institute for Healthcare Research, INTEGRIS Baptist Medical Center of Oklahoma, Oklahoma City 73112, USA.
Gut. 1997 Sep;41(3):390-3. doi: 10.1136/gut.41.3.390.
Recently, several studies have shown an alteration in bowel function during sleep in patients with irritable bowel syndrome (IBS), and a recent study also suggests a remarkable increase in rapid eye movement (REM) sleep. These studies have suggested that an alteration in CNS function may play an important role in the pathogenesis of IBS.
To confirm the presence of an alteration in REM sleep in patients with IBS and to assess the relation between sleep and a non-invasive measure of gastric functioning, the electrogastrogram (EGG).
Ten patients with IBS and 10 age and sex matched normal volunteers.
All subjects slept one night in the sleep laboratory and underwent polysomnographic monitoring to determine sleep patterns, and recording of the EGG from surface electrodes.
The IBS group had a notable and significant increase in the percentage and duration of REM sleep (p < 0.05). The control group had a decrease in the amplitude of the dominant EGG frequency from waking to non-REM sleep (p < 0.05), and a subsequent increase in the amplitude from non-REM to REM sleep (p < 0.05). No such changes were noted in the patients with IBS.
Results confirmed the enhancement of REM sleep in patients with IBS and suggested an intrinsic alteration in autonomic and CNS functioning in patients with IBS.
最近，多项研究表明肠易激综合征（IBS）患者在睡眠期间肠道功能会发生改变，并且最近一项研究还提示快速眼动（REM）睡眠显著增加。这些研究表明中枢神经系统（CNS）功能改变可能在IBS发病机制中起重要作用。
证实IBS患者存在REM睡眠改变，并评估睡眠与胃功能的一种非侵入性测量方法——胃电图（EGG）之间的关系。
10例IBS患者以及10名年龄和性别相匹配的正常志愿者。
所有受试者在睡眠实验室睡一晚，接受多导睡眠图监测以确定睡眠模式，并通过表面电极记录EGG。
IBS组REM睡眠的百分比和持续时间显著增加（p < 0.05）。对照组从清醒到非快速眼动睡眠期间，优势EGG频率的振幅降低（p < 0.05），随后从非快速眼动睡眠到快速眼动睡眠期间振幅增加（p < 0.05）。IBS患者未观察到此类变化。
结果证实IBS患者REM睡眠增强，并提示IBS患者自主神经和中枢神经系统功能存在内在改变。
