从人体尸检组织中检测麻疹病毒信使核糖核酸
Detection of measles virus mRNA from autopsied human tissues.
作者信息
Katayama Y, Kohso K, Nishimura A, Tatsuno Y, Homma M, Hotta H
机构信息
Department of Microbiology, Kobe University School of Medicine, Hyogo, Japan.
出版信息
J Clin Microbiol. 1998 Jan;36(1):299-301. doi: 10.1128/JCM.36.1.299-301.1998.
Abstract
By reverse transcription-PCR, measles virus (MV) mRNA was detected in the brain, kidney, spleen, liver, and lung tissues obtained from 23 (45.1%) of 51 autopsy subjects, with the detection rates of each tissue ranging from 8 to 20%. Sequence analysis revealed frequent mutations in the corresponding viral protein. These results suggest that MV mutants commonly persist in apparently healthy individuals.
摘要
通过逆转录聚合酶链反应，在51例尸检对象中的23例（45.1%）的脑、肾、脾、肝和肺组织中检测到麻疹病毒（MV）mRNA，各组织的检测率在8%至20%之间。序列分析显示相应病毒蛋白中存在频繁突变。这些结果表明，MV突变体通常在表面健康的个体中持续存在。
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