Zhu Y I, Haas J D
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.
Am J Clin Nutr. 1998 Feb;67(2):271-5. doi: 10.1093/ajcn/67.2.271.
Serum transferrin receptor (sTfR) concentration has been recognized recently as a reliable indicator of functional iron deficiency, but its response to iron supplementation has not been investigated in marginally iron-deficient women. In this randomized, double-blinded trial, 37 female subjects aged 19-35 y with iron depletion without anemia (hemoglobin > 120 g/L and serum ferritin < 16 microg/L) received an iron supplement or placebo for 8 wk. Iron status was measured before treatment, after 4 wk of treatment, and posttreatment (ie, after 8 wk of treatment). Iron supplementation of these iron-depleted, nonanemic women resulted in a progressive and significant decrease in sTfR and a significant increase in serum ferritin, and prevented a fall in hemoglobin. The responsiveness of sTfR to iron treatment indicated that sTfR is a sensitive indicator of marginal iron deficiency in iron-depleted, nonanemic women, even when their body iron stores were being replenished.
血清转铁蛋白受体（sTfR）浓度最近已被公认为功能性缺铁的可靠指标，但尚未对边缘性缺铁女性补充铁剂后的反应进行研究。在这项随机双盲试验中，37名年龄在19 - 35岁、缺铁但无贫血（血红蛋白> 120 g/L且血清铁蛋白< 16 μg/L）的女性受试者接受了铁补充剂或安慰剂治疗8周。在治疗前、治疗4周后以及治疗后（即治疗8周后）测量铁状态。对这些缺铁且无贫血的女性补充铁剂导致sTfR逐渐显著下降，血清铁蛋白显著增加，并防止了血红蛋白下降。sTfR对铁治疗的反应表明，sTfR是缺铁且无贫血女性边缘性缺铁的敏感指标，即使她们的体内铁储存正在得到补充。
