Ippoliti A F, Maxwell V, Isenberg J I
Ann Intern Med. 1976 Mar;84(3):286-9. doi: 10.7326/0003-4819-84-3-286.
Milk is commonly recommended as therapy for patients with peptic ulcer. The purpose of this study was to examine the effect of various forms of milk and 0.15 M NaCl (control) on gastric-acid secretion in five patients with duodenal ulcer during a period of remission and in five normal subjects. A significant (P less than 0.05) increase in acid secretion in both groups was produced by 240 ml of whole, low-fat, and nonfat milk. The acid secretory responses to milk were equivalent to approximately 20% to 35% of maximal betazole - or pentagastrin-stimulated acid output. Gastric-acid secretion produced a significant (P less than 0.05) increase in acid secretion in the patients with duodenal ulcer but not in the normal subjects. Because milk contains both protein and calcium, and each are stimulants of gastric-acid secretion, there is reason to question its frequent ingestion by patients with peptic ulcer.
牛奶通常被推荐作为消化性溃疡患者的治疗方法。本研究的目的是在五名十二指肠溃疡缓解期患者和五名正常受试者中，研究不同形式的牛奶和0.15M氯化钠（对照）对胃酸分泌的影响。240毫升全脂、低脂和脱脂牛奶均使两组的胃酸分泌显著增加（P<0.05）。牛奶引起的胃酸分泌反应相当于最大倍他唑或五肽胃泌素刺激胃酸分泌量的约20%至35%。胃酸分泌在十二指肠溃疡患者中引起了显著的胃酸分泌增加（P<0.05），但在正常受试者中未引起。由于牛奶既含有蛋白质又含有钙，而两者都是胃酸分泌的刺激物，因此有理由质疑消化性溃疡患者频繁饮用牛奶的做法。
