van Someren E J, Vonk B F, Thijssen W A, Speelman J D, Schuurman P R, Mirmiran M, Swaab D F
Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, The Netherlands.
IEEE Trans Biomed Eng. 1998 Mar;45(3):386-95. doi: 10.1109/10.661163.
Actigraphy, the long-term measurement of human movement with a small solid state recorder, is gaining acceptance as a useful method in many research fields. Currently available actigraphs assess or estimate the movement duration per time interval. However, the output gives no information on movement type or intensity, and cannot be used in subjects suffering from tremor. The present paper describes a new type of actigraph, that has been developed primarily for the long-term evaluation of motor symptoms in Parkinson patients. The device is the first to discriminate tremor from other movements and to assess both duration and intensity of the two types of movement. It is based on a Motorola 68HC805B6 microcontroller and contains: an accelerometer, programmable gain stages, programmable low- and highpass filters, a programmable level comparator, a peak detector, interface circuits, a real time clock, data storage, and control circuitry. The micro-controller performs a period amplitude sequence analysis (PASA) on the conditioned accelerometer signal, and stores four output variables (tremor duration, tremor amplitude, movement duration, and movement amplitude) at the end of programmable time intervals. The analysis of fluctuations in the motor symptoms of, e.g., Parkinson patients using this actigraph can be of great help in the pharmacological management of symptoms.
活动记录仪，即使用小型固态记录器对人体运动进行长期测量，正在成为许多研究领域中一种有用的方法而被广泛接受。目前可用的活动记录仪可评估或估计每个时间间隔内的运动持续时间。然而，其输出并未提供有关运动类型或强度的信息，并且不能用于患有震颤的受试者。本文描述了一种新型活动记录仪，它主要是为长期评估帕金森病患者的运动症状而开发的。该设备是首个能够区分震颤与其他运动，并能评估这两种运动的持续时间和强度的仪器。它基于摩托罗拉68HC805B6微控制器，包含：一个加速度计、可编程增益级、可编程低通和高通滤波器、一个可编程电平比较器、一个峰值检测器、接口电路、一个实时时钟、数据存储和控制电路。微控制器对经过调节的加速度计信号执行周期幅度序列分析（PASA），并在可编程时间间隔结束时存储四个输出变量（震颤持续时间、震颤幅度、运动持续时间和运动幅度）。使用这种活动记录仪对例如帕金森病患者的运动症状波动进行分析，对症状的药物治疗可能会有很大帮助。
