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腹主动脉瘤破裂:影响术后死亡率和长期生存率的因素

Ruptured abdominal aortic aneurysms: factors influencing postoperative mortality and long-term survival.

作者信息

van Dongen H P, Leusink J A, Moll F L, Brons F M, de Boer A

机构信息

Department of Anaesthesiology, St. Antonius Hospital, Nieuwegein, The Netherlands.

出版信息

Eur J Vasc Endovasc Surg. 1998 Jan;15(1):62-6. doi: 10.1016/s1078-5884(98)80074-9.

Abstract

OBJECTIVE

To update mortality rates and long-term survival of patients admitted to the hospital with ruptured abdominal aortic aneurysm (AAA) and to study prognostic factors associated with mortality.

DESIGN

Retrospective follow-up.

MATERIALS

309 patients (274 men, 35 women, average age 71) admitted to the hospital between January 1980 and January 1994 who were surgically treated for ruptured AAA were studied.

METHODS

To identify the preoperative (9), intraoperative (23) and postoperative (49) variables associated with mortality logistic regression analysis (mortality within 48 h) and Cox regression analysis (mortality between 48 h and 30 days) were performed.

RESULTS

Hospital mortality improved from 1980 to 1994. Compared with the normal population adjusted for age and sex the long-term mortality rate was increased (standardised mortality ratio 2.1; 95% confidence interval 1.7-2.5). Increased age, peroperative hypotension and need for a bifurcated graft were associated with significantly increased mortality. Co-morbidity was not a predictive variable. Overall hospital mortality was 25%.

CONCLUSION

Surgical repair of ruptured AAA should be considered even in patients with co-morbidity. Elderly patients with severe preoperative hypotension have a very high mortality rate and surgery may not be justified in these cases. Long-term survival is also worse in older patients.

摘要

目的

更新腹主动脉瘤破裂(AAA)入院患者的死亡率和长期生存率,并研究与死亡率相关的预后因素。

设计

回顾性随访。

材料

研究了1980年1月至1994年1月期间因AAA破裂入院并接受手术治疗的309例患者(274例男性,35例女性,平均年龄71岁)。

方法

进行逻辑回归分析(48小时内死亡率)和Cox回归分析(48小时至30天内死亡率),以确定与死亡率相关的术前(9项)、术中(23项)和术后(49项)变量。

结果

1980年至1994年期间医院死亡率有所改善。与根据年龄和性别调整后的正常人群相比,长期死亡率有所增加(标准化死亡率2.1;95%置信区间1.7 - 2.5)。年龄增加、术中低血压和需要分叉移植物与死亡率显著增加相关。合并症不是一个预测变量。总体医院死亡率为25%。

结论

即使是合并症患者,也应考虑对破裂AAA进行手术修复。术前严重低血压的老年患者死亡率非常高,在这些情况下手术可能不合理。老年患者的长期生存率也较差。

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