Leidy N K, Coughlin C
Center for Health Outcomes Research, MEDTAP International, Inc., Bethesda, MD 20814, USA.
Qual Life Res. 1998 Feb;7(2):127-34. doi: 10.1023/a:1008853325724.
The purpose of this study was to examine the psychometric characteristics of the Juniper Asthma Quality of Life Questionnaire (AQLQ) in a sample of asthmatics from the USA, employing data from the Asthma Symptom Utility Index (ASUI) validation study. One hundred and sixty-one adults (66 men) undergoing standard care in an asthma clinic participated in the study (mean age = 34.7 +/- 10.7 years, mean duration of illness = 17.3 +/- 11.22 years and mean FEV1% predicted = 85.6% +/- 17.1%). The internal consistency reliability (infinity) ranged from 0.90 (environment subscale) to 0.95 (overall score) and the 2 week reproducibility (ICC) ranged from 0.81 (activities subscale) to 0.93 (symptoms subscale). The AQLQ was significantly correlated with an asthma disease severity scale and the Health Utilities Index (p < 0.001). No relationship was found between the AQLQ score and FEV1% predicted. Men reported better overall quality of life (QoL), fewer activity limitations and less environmental exposure than women (p < 0.01), while patients with a high school education or less had more severe asthma and poorer QoL across all subscales (p < 0.001). This may reflect the differential experiences of asthma across gender and socioeconomic groups. The results suggest that the AQLQ may be a useful outcome measure for clinical trials conducted in the USA.
本研究旨在利用哮喘症状效用指数（ASUI）验证研究的数据，检验美国哮喘患者样本中朱尼珀哮喘生活质量问卷（AQLQ）的心理测量特征。161名在哮喘诊所接受标准治疗的成年人（66名男性）参与了该研究（平均年龄=34.7±10.7岁，平均病程=17.3±11.22年，平均预测FEV1%=85.6%±17.1%）。内部一致性信度（无限）范围从0.90（环境子量表）到0.95（总分），2周重测信度（ICC）范围从0.81（活动子量表）到0.93（症状子量表）。AQLQ与哮喘疾病严重程度量表和健康效用指数显著相关（p<0.001）。未发现AQLQ得分与预测FEV1%之间存在关联。男性报告的总体生活质量（QoL）更好，活动受限更少，环境暴露更少，优于女性（p<0.01），而高中及以下学历的患者在所有子量表上哮喘更严重，QoL更差（p<0.001）。这可能反映了哮喘在性别和社会经济群体中的不同经历。结果表明，AQLQ可能是美国进行的临床试验中一种有用的结局指标。
