老年女性使用口服避孕药与致命性心肌梗死
Oral contraceptive use in older women and fatal myocardial infarction.
作者信息
Mann J I, Inman W H, Thorogood M
出版信息
Br Med J. 1976 Aug 21;2(6033):445-7. doi: 10.1136/bmj.2.6033.445.
A previous study of women who had died from myocardial infarction and of a control group of women matched with them for age suggested a fivefold increase in the risk of death from myocardial infarction among users of oral contraceptive aged 40-44 years compared with women not using such preparations. Only a small proportion of women in the infarction and control groups had used oral contraceptives, however, so the margin of error was wide. We therefore investigated a further 54 women in this age group who died from myocardial infarction and compared their oral contraceptive histories with those of age-matched, living controls. Combination of the findings from the present investigation with the previous results have enabled a revised estimate of a threefold increase in risk to be made. Although this risk estimate is similar to that previously shown for a younger age group, the total mortality attributable to complications associated with the use of oral contraceptives remained considerably greater among women over the age of 40.
一项针对死于心肌梗死的女性以及与之年龄匹配的女性对照组的前期研究表明，40至44岁口服避孕药的女性死于心肌梗死的风险相较于未使用此类药物的女性增加了五倍。然而，梗死组和对照组中仅有一小部分女性使用过口服避孕药，因此误差幅度较大。为此，我们又调查了该年龄组中另外54名死于心肌梗死的女性，并将她们的口服避孕药使用史与年龄匹配的在世对照组进行了比较。将本次调查结果与之前的结果相结合，使得我们能够对风险增加三倍进行修正估计。尽管这一风险估计与之前在较年轻年龄组中显示的结果相似，但40岁以上女性中因使用口服避孕药相关并发症导致的总死亡率仍然相当高。
Zotero 插件