Capitanio J P, Mendoza S P, Lerche N W, Mason W A
California Regional Primate Research Center, University of California, One Shields Avenue, Davis, CA 95616, USA.
Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4714-9. doi: 10.1073/pnas.95.8.4714.
From early in the AIDS epidemic, psychosocial stressors have been proposed as contributors to the variation in disease course. To test this hypothesis, rhesus macaques were assigned to stable or unstable social conditions and were inoculated with the simian immunodeficiency virus. Animals in the unstable condition displayed more agonism and less affiliation, shorter survival, and lower basal concentrations of plasma cortisol compared with stable animals. Early after inoculation, but before the emergence of group differences in cortisol levels, animals receiving social threats had higher concentrations of simian immunodeficiency virus RNA in plasma, and those engaging in affiliation had lower concentrations. The results indicate that social factors can have a significant impact on the course of immunodeficiency disease. Socially induced changes in pituitary-adrenal hormones may be one mechanism mediating this relationship.
自艾滋病流行初期以来，社会心理压力源就被认为是导致疾病进程差异的因素之一。为了验证这一假设，将恒河猴置于稳定或不稳定的社会环境中，并接种猿猴免疫缺陷病毒。与处于稳定环境中的动物相比，处于不稳定环境中的动物表现出更多的争斗行为和更少的亲和行为，存活时间更短，血浆皮质醇基础浓度更低。在接种后早期，但在皮质醇水平出现组间差异之前，受到社会威胁的动物血浆中猿猴免疫缺陷病毒RNA浓度较高，而表现出亲和行为的动物浓度较低。结果表明，社会因素可对免疫缺陷疾病的进程产生重大影响。社会诱导的垂体-肾上腺激素变化可能是介导这种关系的一种机制。
