Rueda A, Zubía E, Ortega M J, Carballo J L, Salvá J
Departamento de Química Orgánica, Facultad de Ciencias del Mar, Universidad de Cádiz, Spain.
J Nat Prod. 1998 Feb;61(2):258-61. doi: 10.1021/np970390b.
The sponge Spongia agaricina from Tarifa, Cadiz, Spain, contains two new 9,11-secosterols, [3-0-deacetylluffasterol B (1) and 3-0-deacetyl-22,23-dihydro-24,28-dehydroluffasterol B (2)] and two new sesterterpenoids [12,16-di-epi-12-0-deacetyl-16-0-acetylfuroscalarol (3) and 16-epi-scalarolbutenolide (4)], in addition to the known compounds 5-15. The structures of all compounds were elucidated by interpretation of' spectroscopic data. The metabolites 1-3 showed significant cytotoxicity against four tumor cell lines (C50 1 microgram/mL).
来自西班牙加的斯塔里法的真菌海绵Spongia agaricina含有两种新的9,11-断甾醇，[3-O-去乙酰基卢法甾醇B（1）和3-O-去乙酰基-22,23-二氢-24,28-脱氢卢法甾醇B（2）]以及两种新的倍半萜类化合物[12,16-二表-12-O-去乙酰基-16-O-乙酰基呋喃鲨胆醇（3）和16-表鲨胆醇丁烯内酯（4）]，此外还有已知化合物5-15。所有化合物的结构通过光谱数据解析得以阐明。代谢产物1-3对四种肿瘤细胞系显示出显著的细胞毒性（半数抑制浓度为1微克/毫升）。
