Kassas A L
Szent László Hospital, Budapest, Hungary.
Acta Microbiol Immunol Hung. 1997;44(4):327-42.
Clinical, epidemiological features of acute viral hepatitis of 331 hospitalized adult patients were evaluated. HA, HB, HC, and non A-C H were diagnosed in 36.6%, 34.1%, 10.6%, and 18.7%, respectively. Age of HA cases was significantly lower than that of other cases. Only HA showed seasonal variation. Acquisition of HA was often associated with visits in endemic areas when compared with all other types, while HB, HC, and non A-C H were rather associated with iatrogenic events (blood transfusion, surgical procedures, and hospitalization). Symptoms of fever and diarrhea, and high ESR were more frequent in HA than in other types, while signs of weight loss and high levels of ALT, AST, and S.T.B, and decreased PT index were significantly more frequent in HB. Cholestasis course was found in 1.7%, 0.9%, and 3.2% of patients with HA, HB, and non A-C H, respectively. Fulminant course was found only in 0.9% of HB patients. Factors as sex and age had no effect on severity of acute phase in HA, HC, and non A-C H, while only the age of patients was inversely associated with severity of acute phase in H B.
对331例住院成年急性病毒性肝炎患者的临床和流行病学特征进行了评估。甲型肝炎（HA）、乙型肝炎（HB）、丙型肝炎（HC）和非甲-非丙型肝炎（non A-C H）的诊断率分别为36.6%、34.1%、10.6%和18.7%。HA患者的年龄显著低于其他病例。仅HA呈现季节性变化。与所有其他类型相比，HA的感染常与疫区访问有关，而HB、HC和非甲-非丙型肝炎则更多与医源性事件（输血、外科手术和住院）有关。HA患者发热和腹泻症状以及血沉增快比其他类型更为常见，而体重减轻、谷丙转氨酶（ALT）、谷草转氨酶（AST）和总胆红素（S.T.B）水平升高以及凝血酶原指数降低等体征在HB患者中显著更为常见。HA、HB和非甲-非丙型肝炎患者出现胆汁淤积病程的比例分别为1.7%、0.9%和3.2%。暴发性病程仅在0.9%的HB患者中出现。性别和年龄等因素对HA、HC和非甲-非丙型肝炎急性期的严重程度无影响，而仅患者年龄与HB急性期的严重程度呈负相关。
