Andersson A, Granum P E, Rönner U
Department of Food Science, SIK, Swedish Institute for Food and Biotechnology, Gothenburg, Sweden.
Int J Food Microbiol. 1998 Jan 6;39(1-2):93-9. doi: 10.1016/s0168-1605(97)00121-9.
Four out of ten Bacillus cereus strains produced spores able to adhere to monolayers of Caco-2 cells (human epithelial cells). One of these strains has been involved in an outbreak of food poisoning where the symptoms were more severe and persisted for longer than a normal B. cereus food poisoning. The hydrophobicity of the spores is a contributing factor for the adhesion to occur. The spores are able to germinate in an environment similar to that of the small intestine and then the vegetative cells can produce the enterotoxin directly at the target place. A concentrated and active form of the enterotoxin will be taken up by the epithelial cells in the small intestine. Spore adhesion could be an important virulence factor for some B. cereus strains.
十分之四的蜡样芽孢杆菌菌株产生的孢子能够黏附于Caco-2细胞（人上皮细胞）单层。其中一个菌株曾引发食物中毒暴发，其症状比正常蜡样芽孢杆菌食物中毒更严重且持续时间更长。孢子的疏水性是发生黏附的一个促成因素。孢子能够在类似于小肠的环境中萌发，然后营养细胞可直接在目标部位产生肠毒素。小肠上皮细胞会摄取浓缩且有活性形式的肠毒素。孢子黏附可能是某些蜡样芽孢杆菌菌株的一个重要毒力因子。
