憩室病中的克罗恩样反应。
Crohn's-like reaction in diverticular disease.
作者信息
Gledhill A, Dixon M F
机构信息
Department of Histopathology, Harrogate General Hospital, UK.
出版信息
Gut. 1998 Mar;42(3):392-5. doi: 10.1136/gut.42.3.392.
BACKGROUND
Diverticulitis and Crohn's disease affecting the colon occur at similar sites in older individuals, and in combination are said to carry a worse prognosis than either disease in isolation. It is possible that diverticulitis may initiate inflammatory changes which resemble Crohn's disease histologically, but do not carry the clinical implications of chronic inflammatory bowel disease.
AIMS
To evaluate histological features and clinical outcome in individuals initially diagnosed histologically as having both Crohn's colitis and diverticulitis.
PATIENTS
Eleven consecutive individuals having a colonic resection showing histological features of both Crohn's disease and diverticulitis.
METHODS
Retrospective review of histological specimens, case notes, and discharge letters.
RESULTS
In nine patients, the Crohn's-like reaction was confined to the segment bearing diverticula. They had no clinical evidence of Crohn's disease.
CONCLUSION
A Crohn's-like inflammatory response can be a localised reaction to diverticulitis and does not necessarily indicate chronic inflammatory bowel disease.
背景
憩室炎和影响结肠的克罗恩病在老年个体中发生于相似部位，据说二者合并存在时的预后比单独任何一种疾病都更差。憩室炎有可能引发组织学上类似于克罗恩病的炎症改变，但不具有慢性炎症性肠病的临床意义。
目的
评估最初经组织学诊断同时患有克罗恩结肠炎和憩室炎的个体的组织学特征和临床结局。
患者
11例接受结肠切除术的连续患者，其组织学表现兼具克罗恩病和憩室炎的特征。
方法
对组织学标本、病历记录和出院小结进行回顾性分析。
结果
9例患者中，类似克罗恩病的反应局限于有憩室的节段。他们没有克罗恩病的临床证据。
结论
类似克罗恩病的炎症反应可能是对憩室炎的局部反应，不一定表明患有慢性炎症性肠病。
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