Buckley M J, O'Morain C A
Service de Hepato-Gastroenterologie, Hôpital de l'Archet II, CHU, Nice, France.
Br Med Bull. 1998;54(1):7-16. doi: 10.1093/oxfordjournals.bmb.a011681.
The presence of gastric spirochaetal organisms was first documented over a century ago. Though repeatedly reported in the medical literature, it was felt that these spiral bacteria were merely contaminants and the reports were generally ignored by the medical community. On 22 October 1982, at a meeting of the Royal Australian College of Physicians, successful culture of these 'Campylobacterlike organisms' from gastric biopsy specimens was reported for the first time. Moreover, it was shown that their presence was associated with gastritis and, possibly, with peptic ulceration. The subsequent discovery of the pivotal role of Helicobacter pylori in a wide range of conditions has revolutionised our understanding of gastroduodenal diseases. Improvements in diagnostic and therapeutic options, combined with the gradual acceptance of the aetiological role of an infective agent in peptic disease, have led to a remarkable change in the management of gastroduodenal conditions in the past decade.
胃螺旋体生物的存在早在一个多世纪前就有记录。尽管在医学文献中反复报道，但人们认为这些螺旋细菌仅仅是污染物，这些报道通常被医学界忽视。1982年10月22日，在澳大利亚皇家内科医师学院的一次会议上，首次报道了从胃活检标本中成功培养出这些“弯曲菌样生物”。此外，研究表明它们的存在与胃炎以及可能的消化性溃疡有关。随后发现幽门螺杆菌在多种疾病中的关键作用，彻底改变了我们对胃十二指肠疾病的理解。在过去十年中，诊断和治疗选择的改善，加上人们逐渐接受感染因子在消化性疾病中的病因学作用，导致了胃十二指肠疾病管理的显著变化。
