Kitazawa Y
Am J Ophthalmol. 1976 Sep;82(3):492-5. doi: 10.1016/0002-9394(76)90500-6.
Twelve patients who were highly responsive to topically administered betamethasone were subjected to various corticosteroid preparations (four times daily for four weeks). Each patient was tested in the same eye with fluorometholone, tetrahydrotriamcinolone, medrysone, and betamethasone and the potential to elvate intraocular pressure was determined. The response of intraocular pressure to all the corticosteroids was dose-related and a highly significant correlation was demonstrated between the concentration of betamethasone and the magnitude of intraocular pressure response. The order of potential of corticosteroids to elevate IOP was betamethasone 0.1%, betamethasone 0.05%, tetrahydrotriamcinolone 1.25%, betamethasone 0.02%, fluorometholone 0.1%, medrysone 1.0%, and betamethasone 0.01%. Tetrahydrotriamcinolone 0.25% and fluorometholone 0.05 and 0.01% failed to elevate intraocular pressure significantly.
对局部应用倍他米松反应强烈的12名患者接受了各种皮质类固醇制剂治疗（每日4次，共4周）。对每位患者的同一只眼睛使用氟米龙、四氢曲安西龙、甲羟松和倍他米松进行测试，并测定眼压升高的可能性。眼压对所有皮质类固醇的反应都与剂量相关，并且倍他米松浓度与眼压反应幅度之间存在高度显著的相关性。皮质类固醇升高眼压的可能性顺序为：0.1%倍他米松、0.05%倍他米松、1.25%四氢曲安西龙、0.02%倍他米松、0.1%氟米龙、1.0%甲羟松和0.01%倍他米松。0.25%四氢曲安西龙以及0.05%和0.01%氟米龙未能显著升高眼压。
