Oura C A, Powell P P, Anderson E, Parkhouse R M
Institute for Animal Health, Pirbright Laboratory, Surrey, UK.
J Gen Virol. 1998 Jun;79 ( Pt 6):1439-43. doi: 10.1099/0022-1317-79-6-1439.
Bushpigs and warthogs are natural reservoir hosts of African swine fever virus (ASFV) in the wild, showing no clinical signs of disease when infected with the same highly virulent isolates of ASFV that induce rapid, haemorrhagic death in domestic pigs. In contrast to domestic pigs, infection of bushpigs with Malawi isolate results in low levels of virus replication and lymphocyte apoptosis within the spleen, and a relatively low spread of virus to other lymphoid tissues. However, at 10 days post-infection, a high degree of apoptosis was seen in B lymphocytes of the B cell follicles in bushpig lymph nodes. Virus infected cells were present amongst the apoptotic B cells of these follicles, suggesting that indirect factors released from ASFV infected macrophages signal surrounding lymphocytes to enter apoptosis. The susceptibility/resistance of domestic pigs/bushpigs to ASFV may serve as a unique veterinary model for the recently emerging haemorrhagic disease of man.
丛林猪和疣猪是非洲猪瘟病毒（ASFV）在野外的天然宿主，当感染与在家猪中能引发快速出血性死亡的相同高致病性ASFV毒株时，它们没有疾病的临床症状。与家猪不同，丛林猪感染马拉维毒株会导致脾脏内病毒复制水平较低、淋巴细胞凋亡，并且病毒向其他淋巴组织的传播相对较少。然而，在感染后10天，在丛林猪淋巴结的B细胞滤泡中的B淋巴细胞中观察到高度凋亡。病毒感染的细胞存在于这些滤泡的凋亡B细胞中，这表明从ASFV感染的巨噬细胞释放的间接因子向周围淋巴细胞发出信号使其进入凋亡状态。家猪/丛林猪对ASFV的易感性/抗性可能成为一种针对人类最近出现的出血性疾病的独特兽医模型。
