Jansen S, Lopez-Miranda J, Salas J, Castro P, Paniagua J A, Lopez-Segura F, Ordovas J M, Jimenez-Pereperez J A, Blanco A, Perez-Jimenez F
Lipid Research Unit, University Hospital Reina Sofia, University of Cordoba Medical School, Cordoba 14004, Spain.
J Nutr. 1998 Jul;128(7):1144-9. doi: 10.1093/jn/128.7.1144.
Lipid response to dietary fat is highly variable among individuals of a population. The aim of this study was to establish whether being overweight is one of the factors that determines this response. Forty-one non-obese healthy men were divided into two groups according to body mass index as follows: controls, <25 kg/m2; overweight, >25 kg/m2 but <30 kg/m2. After consuming a saturated fat-rich diet (SAT diet: 38% fat, 20% saturated) for 4 wk, subjects were switched to a low fat diet [National Cholesterol Education Program (NCEP)-I diet: 28% fat, 10% saturated] for 4 wk and then to a monounsaturated fat-rich diet (MUFA diet: 38% fat, 22% monounsaturated) for 4 wk. Data were analyzed by Student's t test and two-way ANOVA for repeated measures. After consuming the NCEP-I diet, the overweight subjects had a smaller decrease relative to the SAT diet period in plasma total cholesterol [-0.30 vs. -0.67 mmol/L (-7 vs. -16%), P < 0.02] and low density lipoprotein-cholesterol concentrations [-0.24 vs. -0.55 mmol/L (-9 vs. -21%), P < 0.04] than controls. However, in the overweight subjects, the MUFA diet produced a greater decrease in plasma triglycerides than in the controls relative to the SAT diet period [-0.36 vs. -0.03 mmol/L (-26 vs. -4%), P < 0.006] and to the NCEP-I diet period [-0.29 vs. 0. 01 mmol/L (-22 vs. 1%), P < 0.01). Plasma cholesterol concentrations changed to a lesser extent, and triglyceride concentration to a greater extent, in overweight but non-obese young men than in those of normal weight in response to changes in dietary fat composition. Our data suggest that in the diet treatment of obese hyperlipemic subjects, it is more important for them to lose weight than to change the fat composition of their diets.
人群中个体对膳食脂肪的脂质反应差异很大。本研究的目的是确定超重是否是决定这种反应的因素之一。41名非肥胖健康男性根据体重指数分为两组，如下：对照组，<25kg/m²；超重组，>25kg/m²但<30kg/m²。在食用富含饱和脂肪的饮食（饱和脂肪饮食：38%脂肪，20%饱和脂肪）4周后，受试者改为低脂饮食[国家胆固醇教育计划（NCEP）-I饮食：28%脂肪，10%饱和脂肪]4周，然后改为富含单不饱和脂肪的饮食（MUFA饮食：38%脂肪，22%单不饱和脂肪）4周。数据采用学生t检验和重复测量的双向方差分析进行分析。食用NCEP-I饮食后，超重受试者相对于饱和脂肪饮食期血浆总胆固醇[−0.30 vs.−0.67 mmol/L（−7 vs.−16%），P<0.02]和低密度脂蛋白胆固醇浓度[−0.24 vs.−0.55 mmol/L（−9 vs.−21%），P<0.04]的下降幅度小于对照组。然而，相对于饱和脂肪饮食期[−0.36 vs.−0.03 mmol/L（−26 vs.−4%），P<0.006]和NCEP-I饮食期[−0.29 vs.0.01 mmol/L（−22 vs.1%），P<0.01]，超重受试者中，MUFA饮食使血浆甘油三酯的下降幅度大于对照组。与正常体重的年轻男性相比，超重但非肥胖的年轻男性对膳食脂肪组成变化的反应中，血浆胆固醇浓度变化较小，甘油三酯浓度变化较大。我们的数据表明，在肥胖高脂血症受试者的饮食治疗中，对他们来说，减肥比改变饮食中的脂肪组成更重要。
