白细胞介素-11在类风湿关节炎炎症过程中的重要免疫调节作用。
Important immunoregulatory role of interleukin-11 in the inflammatory process in rheumatoid arthritis.
作者信息
Hermann J A, Hall M A, Maini R N, Feldmann M, Brennan F M
机构信息
The Mathilda and Terence Kennedy Institute of Rheumatology, London, UK.
出版信息
Arthritis Rheum. 1998 Aug;41(8):1388-97. doi: 10.1002/1529-0131(199808)41:8<1388::AID-ART7>3.0.CO;2-F.
OBJECTIVE
To investigate the possible immunoregulatory role of interleukin-11 (IL-11) in rheumatoid arthritis (RA).
METHODS
IL-11 protein was assayed in RA tissue, and the effect of exogenous IL-11 on neutralization of endogenous IL-11 was investigated with respect to tumor necrosis factor alpha (TNFalpha), matrix metalloproteinase (MMP), and tissue inhibitor of metalloproteinases (TIMP) production.
RESULTS
IL-11 was found in RA synovial membranes, synovial fluids, and blood sera. Blockade of endogenous IL-11 resulted in a 2-fold increase in TNFalpha levels, which increased to 22-fold if endogenous IL-10 was also blocked. Addition of exogenous IL-11 inhibited spontaneous TNFalpha production in RA synovium only in the presence of soluble IL-11 receptor. However, exogenous IL-11 directly inhibited spontaneous MMP-1 and MMP-3 production, and up-regulated TIMP-1 in RA synovial tissue.
CONCLUSION
IL-11 has important endogenous immunoregulatory effects in RA synovium, which suggests that exogenous IL-11 may have therapeutic activity in RA.
目的
研究白细胞介素-11（IL-11）在类风湿关节炎（RA）中可能的免疫调节作用。
方法
检测RA组织中的IL-11蛋白，并就肿瘤坏死因子α（TNFα）、基质金属蛋白酶（MMP）和金属蛋白酶组织抑制剂（TIMP）的产生，研究外源性IL-11对内源性IL-11中和作用的影响。
结果
在RA滑膜、滑液和血清中发现了IL-11。内源性IL-11的阻断导致TNFα水平增加2倍，如果内源性IL-10也被阻断，则增加到22倍。仅在存在可溶性IL-11受体的情况下，添加外源性IL-11才抑制RA滑膜中自发性TNFα的产生。然而，外源性IL-11直接抑制RA滑膜组织中自发性MMP-1和MMP-3的产生，并上调TIMP-1。
结论
IL-11在RA滑膜中具有重要的内源性免疫调节作用，这表明外源性IL-11可能对RA具有治疗活性。
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