脑分化神经元中鲽鱼钙蛋白的高表达。
High expression of stanniocalcin in differentiated brain neurons.
作者信息
Zhang K Z, Westberg J A, Paetau A, von Boguslawsky K, Lindsberg P, Erlander M, Guo H, Su J, Olsen H S, Andersson L C
机构信息
Department of Pathology, Haartman Institute, University of Helsinki, Finland.
出版信息
Am J Pathol. 1998 Aug;153(2):439-45. doi: 10.1016/S0002-9440(10)65587-3.
Abstract
Stanniocalcin (STC) is a glycoprotein hormone first found in fish, in which it regulates calcium homeostasis and protects against hypercalcemia. Human and mouse stc cDNA were recently cloned. We found a dramatically upregulated expression of STC during induced neural differentiation in a human neural crest-derived cell line, Paju. Immunohistochemical staining of sections from human and adult mouse brain revealed abundant presence of STC in the neurons with no activity in the glial cells. STC expression was not seen in immature brain neurons of fetal or newborn mice. Given that STC has been found to regulate calcium/phosphate metabolism in some mammalian epithelia, we suggest that STC may act as a regulator of calcium homeostasis in terminally differentiated brain neurons.
摘要
鲽源钙调蛋白（STC）是一种糖蛋白激素，最初在鱼类中发现，它在鱼类中调节钙稳态并预防高钙血症。人类和小鼠的stc cDNA最近已被克隆。我们发现，在人神经嵴衍生细胞系Paju诱导神经分化过程中，STC的表达显著上调。对人类和成年小鼠大脑切片进行免疫组织化学染色显示，STC在神经元中大量存在，而在神经胶质细胞中无活性。在胎儿或新生小鼠的未成熟脑神经元中未观察到STC表达。鉴于已发现STC在某些哺乳动物上皮细胞中调节钙/磷代谢，我们认为STC可能在终末分化的脑神经元中作为钙稳态的调节因子发挥作用。
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