Lee P A, Bellinger M F, Coughlin M T
Department of Pediatrics, University of Pittsburgh and Children's Hospital of Pittsburgh, Pennsylvania, USA.
J Urol. 1998 Sep;160(3 Pt 2):1155-7; discussion 1178. doi: 10.1097/00005392-199809020-00052.
We compared characteristics related to fertility between formerly unilaterally cryptorchid men.
We compared sperm counts and gonadotropin levels before and after gonadotropin-releasing hormone stimulation between formerly unilaterally cryptorchid men and controls who had completed a detailed questionnaire on fertility and other pertinent paternity information. These parameters were also compared between the subsets of formerly cryptorchid men who reported paternity and unsuccessful attempts at paternity.
Sperm density and total count, and basal and gonadotropin-releasing hormone stimulated follicle-stimulating hormone (FSH) levels were different in the cryptorchidism and control groups. Higher FSH levels and lower sperm counts correlated inversely in the cryptorchidism group, while luteinizing hormone, testosterone and other results of semen analysis did not differ. Furthermore, FSH levels were higher and sperm counts were lower in the subset who reported unsuccessful attempts at paternity compared with those reporting paternity. Other measured parameters did not differ between these groups.
FSH levels are significantly higher and sperm counts are significantly lower in formerly cryptorchid men than in controls. In the cryptorchidism group the same differences are found in fertile and infertile men. Thus, elevated FSH and low sperm counts may be considered risks for infertility in formerly cryptorchid men.
我们比较了既往单侧隐睾男性与生育相关的特征。
我们比较了既往单侧隐睾男性与已完成关于生育及其他相关亲子关系信息详细问卷的对照组在促性腺激素释放激素刺激前后的精子计数和促性腺激素水平。这些参数也在报告有亲子关系和尝试亲子关系未成功的既往隐睾男性亚组之间进行了比较。
隐睾症组与对照组的精子密度和总数，以及基础和促性腺激素释放激素刺激后的促卵泡激素（FSH）水平存在差异。在隐睾症组中，较高的FSH水平与较低的精子计数呈负相关，而黄体生成素、睾酮及精液分析的其他结果无差异。此外，与报告有亲子关系的人相比，报告尝试亲子关系未成功的亚组FSH水平较高，精子计数较低。这些组之间的其他测量参数无差异。
既往隐睾男性的FSH水平显著高于对照组，精子计数显著低于对照组。在隐睾症组中，可育和不育男性也存在同样的差异。因此，FSH升高和精子计数低可能被视为既往隐睾男性不育的风险因素。
