Chen W J, Chen C C, Yu J M, Cheng A T
Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, USA.
Alcohol Clin Exp Res. 1998 Aug;22(5):1048-52.
The aims of this study are to investigate whether self-reported facial flushing postalcohol consumption (PAC) among subjects with ALDH21/1 can be attributed to ADH2 or ADH3 and whether the prediction of ALDH2 genotype can be improved by examining the combination of flushing and other accompanying reactions of PAC sensitivity. Fifty-eight subjects of Han ancestry in Taiwan were interviewed for alcohol-sensitivity reactions and their blood samples were genotyped for ALDH2, ADH2, and ADH3. For subjects with ALDH21/1 (n = 46), 70% reported to have no flushing PAC and 30% reported flushing PAC. When subjects with ALDH21/1 had ADH21/1 (n = 11), all reported to have no flushing; otherwise, 35% (for ADH21/2, n = 17) and 44% (for ADH22/2, n = 18) reported flushing. For subjects with ALDH21/1 and at least one ADH22 allele, the genotype of ADH3 was not associated with self-reported flushing. PAC flushers with ALDH21/1 (50%) were more likely to report nausea than those with ALDH21/2 (8%). The probability of ALDH21/1 given flushing reported was 0.29, while the probability of ALDH21/*1 given both flushing and nausea reported was 0.71. The results indicate that self-reported flushing is determined by both ALDH2 and ADH2 and that prediction of ALDH2 genotype on the basis of self-reported flushing and nausea can help identify subjects at increased risk for alcoholism.
本研究的目的是调查在携带ALDH21/1的受试者中，自我报告的饮酒后脸红（PAC）是否可归因于ADH2或ADH3，以及通过检查脸红与PAC敏感性的其他伴随反应的组合，是否可以改善对ALDH2基因型的预测。对台湾58名汉族受试者进行了酒精敏感性反应访谈，并对他们的血液样本进行了ALDH2、ADH2和ADH3基因分型。对于携带ALDH21/1的受试者（n = 46），70%报告无饮酒后脸红，30%报告有饮酒后脸红。当携带ALDH21/1的受试者同时携带ADH21/1时（n = 11），所有人均报告无脸红；否则，35%（ADH21/2，n = 17）和44%（ADH22/2，n = 18）报告有脸红。对于携带ALDH21/1且至少有一个ADH22等位基因的受试者，ADH3基因型与自我报告的脸红无关。携带ALDH21/1的饮酒后脸红者（50%）比携带ALDH21/2的饮酒后脸红者（8%）更有可能报告恶心。报告有脸红时ALDH21/1的概率为0.29，而报告有脸红且有恶心时ALDH21/*1的概率为0.71。结果表明，自我报告的脸红由ALDH2和ADH2共同决定，并且基于自我报告的脸红和恶心对ALDH2基因型进行预测有助于识别酗酒风险增加的受试者。
