Oliver S G, Winson M K, Kell D B, Baganz F
Department of Biomolecular Sciences, UMIST, Manchester, UK.
Trends Biotechnol. 1998 Sep;16(9):373-8. doi: 10.1016/s0167-7799(98)01214-1.
The genome sequence of the yeast Saccharomyces cerevisiae has provided the first complete inventory of the working parts of a eukaryotic cell. The challenge is now to discover what each of the gene products does and how they interact in a living yeast cell. Systematic and comprehensive approaches to the elucidation of yeast gene function are discussed and the prospects for the functional genomics of eukaryotic organisms evaluated.
酿酒酵母的基因组序列首次完整列出了真核细胞的组成部分。现在面临的挑战是弄清楚每个基因产物的作用以及它们在活酵母细胞中是如何相互作用的。本文讨论了阐明酵母基因功能的系统且全面的方法，并评估了真核生物功能基因组学的前景。
