Rappaport L, Oliviero P, Samuel J L
Unité 127 INSERM, IFR Circulation, University D Diderot, Hôpital Lariboisière, Paris, France.
Mol Cell Biochem. 1998 Jul;184(1-2):101-5.
It has been well established that the cytoskeleton is an essential modulator of cell morphology and motility, intracytoplasmic transport and mitosis, however cytoskeletal linkage to the organelles has not been unequivocally demonstrated. Indeed, cytoskeleton appears to be essential in determining and modulating gene phenotype as a function of cellular environment. According to recent studies, the organization of the cytoskeleton network together with associated protein(s) could be essential in regulating mitochondrial function and particularly the permeability of the mitochondrial outer membrane to ADP. The aim of this chapter is to summarize the main properties of the cytoskeletal environment of mitochondria and the possible role(s) of this network in mitochondrial function in myocytes.
细胞骨架是细胞形态和运动、胞质内运输及有丝分裂的重要调节因子，这一点已得到充分证实。然而，细胞骨架与细胞器的联系尚未得到明确证明。事实上，细胞骨架似乎对于根据细胞环境确定和调节基因表型至关重要。根据最近的研究，细胞骨架网络与相关蛋白质的组织可能对于调节线粒体功能，特别是线粒体外膜对ADP的通透性至关重要。本章的目的是总结线粒体细胞骨架环境的主要特性以及该网络在心肌细胞线粒体功能中的可能作用。
