Liu C S, Kuo H W, Lai J S, Lin T I
Department of Family Medicine, China Medical College Hospital, Taichung, Taiwan, ROC.
Int Arch Occup Environ Health. 1998 Jul;71(5):348-52. doi: 10.1007/s004200050291.
To investigate chromium-induced renal dysfunction in electroplating workers.
A cross-sectional study was used to evaluate four biochemical markers of renal function. A total of 178 workers were divided into 3 comparable groups consisting of 34 hard-chrome plating workers, 98 nickel-chrome electroplating workers. and 46 aluminum anode-oxidation workers, who represented the reference group. Ambient and biological monitoring of urinary chromium were performed to measure exposure concentrations.
Overall, urinary chromium concentrations were highest among hard-chrome plating workers (geometric mean 2.44 microg/g creatinine), followed by nickel-chrome electroplating workers (0.31 microg/g creatinine) and aluminum workers (0.09 microg/g creatinine). Airborne chromium concentrations were also highest in the hard-chrome plating area (geometric mean 4.20 microg/m3), followed by the nickel-chrome electroplating area (0.58 microg/m3) and the aluminum area (0.43 microg/m3). A positive correlation was found between urinary chromium and airborne concentrations (r=0.54, P < 0.01). Urinary concentrations of N-acetyl-beta-D-glucosaminidase (NAG) were also highest among hard-chrome plating workers (geometric mean 4.9 IU/g creatinine), followed by nickel-chrome workers (3.4 IU/g creatinine) and aluminum workers (2.9 IU/g creatinine). The prevalence of "elevated" NAG (>7 IU/g creatinine) was significantly highest among hard-chrome plating workers (23.5%), then among nickel-chrome workers (7.1%) and aluminum workers (8.7%). Differences in beta2-microglobulin, total protein, and microalbumin were not significant.
The author's evidence indicates that NAG is an early indicator of renal dysfunction in hard-chrome plating workers.
研究电镀工人中铬诱导的肾功能障碍。
采用横断面研究评估四项肾功能生化指标。总共178名工人被分为3个可比组，包括34名硬铬电镀工人、98名镍铬电镀工人和46名铝阳极氧化工人（作为参照组）。对尿铬进行环境和生物监测以测量暴露浓度。
总体而言，硬铬电镀工人的尿铬浓度最高（几何均值为2.44微克/克肌酐），其次是镍铬电镀工人（0.31微克/克肌酐）和铝工人（0.09微克/克肌酐）。硬铬电镀区域的空气中铬浓度也最高（几何均值为4.20微克/立方米），其次是镍铬电镀区域（0.58微克/立方米）和铝区域（0.43微克/立方米）。发现尿铬与空气中浓度之间存在正相关（r = 0.54，P < 0.01）。硬铬电镀工人的N - 乙酰 - β - D - 氨基葡萄糖苷酶（NAG）尿浓度也最高（几何均值为4.9国际单位/克肌酐），其次是镍铬工人（3.4国际单位/克肌酐）和铝工人（2.9国际单位/克肌酐）。“升高”的NAG（>7国际单位/克肌酐）患病率在硬铬电镀工人中显著最高（23.5%），其次是镍铬工人（7.1%）和铝工人（8.7%）。β2 - 微球蛋白、总蛋白和微量白蛋白的差异不显著。
作者的证据表明，NAG是硬铬电镀工人肾功能障碍的早期指标。
