Vasankari T J, Kujala U M, Vasankari T M, Ahotupa M
Paavo Nurmi Center, University of Turku, Finland.
Med Sci Sports Exerc. 1998 Oct;30(10):1496-501. doi: 10.1097/00005768-199810000-00005.
We studied the effect of a 10-month exercise program on LDL oxidation and other lipid risk factors in 34 sedentary men and 70 women. We hypothesized that decreasing LDL oxidation by raising exercise activity would decrease the risk of atherosclerosis.
The men and women subjects had a mean (range) age of 43.6 (34-52) and 44.6 (31-58) yr, a body mass of 94.4 (78-144) and 77.6 (56-117) kg, a body mass index of 29.6 (24-44) and 28.6 (21-41), a body fat percentage of 20.4 (13-29) and 31.4 (16-39), and a maximal oxygen uptake of 33.3 (15-50) and 30.4 (18-49) mL.kg-1.min-1, respectively. We measured the baseline levels of conjugated dienes extracted from LDL (LDL-BDC) to assess the amount of circulating LDL oxidation products. The antioxidant potential of LDL samples was estimated in vitro by their potency to resist 2,2'-azobis(2-amidinopropane)HCl-induced peroxidation. The exercise program was tailored individually based on indirect measurement of VO2max at baseline.
The mean time of exercise was 257 min.wk-1 for men and 209 min.wk-1 for women. Estimated VO2max increased by 19% during the exercise program in both men and women (both P < 0.0001). Concurrently, the concentration of HDL cholesterol increased by 15% in men (P = 0.0004) and 5% in women (P = 0.043) and that of LDL cholesterol decreased by 10% (P = 0.026) and 11% (P < 0.0001), respectively, whereas serum total cholesterol and triglyceride concentrations remained unchanged. The concentrations of LDL-BDC decreased by 23% (P = 0.0010) and 26% (P < 0.0001) and the ratio of LDL-BDC to LDL by 14% (P = 0.016) and 18% (P < 0.0001) in men and women. The ratio of LDL antioxidant potential to LDL rose by 16% (P = 0.011) and 11% (P = 0.0016), respectively. The mean weight loss during the exercise program was 2.9 kg in men and 1.8 kg in women (both P < 0.0001), whereas body fat percentage fell by 2.3% and 3.2%, respectively.
In addition to increasing HDL cholesterol and decreasing LDL cholesterol, the exercise program is concluded to have improved the quality of the circulating LDL (less oxidized LDL), which may reduce the risk of atherosclerosis.
我们研究了一项为期10个月的运动计划对34名久坐不动的男性和70名女性低密度脂蛋白（LDL）氧化及其他脂质风险因素的影响。我们假设通过增加运动活动来降低LDL氧化会降低动脉粥样硬化的风险。
男性和女性受试者的平均（范围）年龄分别为43.6（34 - 52）岁和44.6（31 - 58）岁，体重分别为94.4（78 - 144）千克和77.6（56 - 117）千克，体重指数分别为29.6（24 - 44）和28.6（21 - 41），体脂百分比分别为20.4（13 - 29）和31.4（16 - 39），最大摄氧量分别为33.3（15 - 50）和30.4（18 - 49）毫升·千克⁻¹·分钟⁻¹。我们测量了从LDL中提取的共轭二烯（LDL - BDC）的基线水平，以评估循环中LDL氧化产物的量。通过LDL样本抵抗2,2'-偶氮二异丁脒盐酸盐诱导的过氧化的能力，在体外估计LDL样本的抗氧化潜力。运动计划根据基线时对最大摄氧量的间接测量进行个性化定制。
男性的平均运动时间为每周257分钟，女性为每周209分钟。在运动计划期间，男性和女性的估计最大摄氧量均增加了19%（P均<0.0001）。同时，男性的高密度脂蛋白胆固醇（HDL胆固醇）浓度增加了15%（P = 0.0004），女性增加了5%（P = 0.043），而LDL胆固醇浓度分别降低了10%（P = 0.026）和11%（P < 0.0001），而血清总胆固醇和甘油三酯浓度保持不变。男性和女性的LDL - BDC浓度分别降低了23%（P = 0.0010）和26%（P < 0.0001），LDL - BDC与LDL的比率分别降低了14%（P = 0.016）和18%（P < 0.0001）。LDL抗氧化潜力与LDL的比率分别上升了16%（P = 0.011）和11%（P = 0.0016）。运动计划期间男性平均体重减轻2.9千克，女性减轻1.8千克（P均<0.0001），而体脂百分比分别下降了2.3%和3.2%。
除了增加HDL胆固醇和降低LDL胆固醇外，该运动计划还改善了循环中LDL的质量（氧化的LDL减少），这可能降低动脉粥样硬化的风险。
