Anttila T I, Lehtinen T, Leinonen M, Bloigu A, Koskela P, Lehtinen M, Saikku P
National Public Health Institute, Oulu, Finland.
Br J Haematol. 1998 Oct;103(1):150-6. doi: 10.1046/j.1365-2141.1998.00942.x.
Chronic infections may predispose to malignant growth. Recently, serological markers of chronic Chlamydia pneumoniae infection have been associated with lung cancer. Our aim was to study the possible association between chronic chlamydial infections and malignant lymphomas. The present case-control study involved 72 patients with lymphoma (31 females and 41 males) and matched controls. 53 patients had non-Hodgkin's lymphoma (NHL) and 19 had Hodgkin's disease. The sera, collected at the time of diagnosis, were tested for IgG antibodies and immune complexes to C. pneumoniae and C. trachomatis by a microimmunofluorescence method and ELISA and for IgG antibodies and immune complexes to Helicobacter pylori by ELISA. The serological markers suggesting chronic chlamydial infection were associated with malignant lymphoma. The association was most evident for the presence of C. pneumoniae-specific immune complexes in NHL (OR = 7.3, 95% CI 2.2-25) and appeared to be limited to men. No association between H. pylori antibodies or immune complexes and malignant lymphomas could be demonstrated. Our study provides seroepidemiological evidence of an association between chronic chlamydial infections and lymphomas.
慢性感染可能易引发恶性肿瘤。最近，慢性肺炎衣原体感染的血清学标志物已与肺癌相关联。我们的目的是研究慢性衣原体感染与恶性淋巴瘤之间可能存在的关联。本病例对照研究纳入了72例淋巴瘤患者（31名女性和41名男性）以及匹配的对照组。53例患者患有非霍奇金淋巴瘤（NHL），19例患有霍奇金病。通过微量免疫荧光法和酶联免疫吸附测定（ELISA）检测诊断时采集的血清中针对肺炎衣原体和沙眼衣原体的IgG抗体及免疫复合物，并用ELISA检测针对幽门螺杆菌的IgG抗体及免疫复合物。提示慢性衣原体感染的血清学标志物与恶性淋巴瘤相关。这种关联在NHL中肺炎衣原体特异性免疫复合物的存在方面最为明显（比值比=7.3，95%可信区间2.2 - 25），且似乎仅限于男性。未发现幽门螺杆菌抗体或免疫复合物与恶性淋巴瘤之间存在关联。我们的研究提供了慢性衣原体感染与淋巴瘤之间存在关联的血清流行病学证据。
