Tunney M M, Ramage G, Patrick S, Nixon J R, Murphy P G, Gorman S P
Department of Microbiology and Immunobiology, School of Clinical Medicine, The Queen's University of Belfast, Belfast BT12 6BN, Belfast BT9 7BL, United Kingdom.
Antimicrob Agents Chemother. 1998 Nov;42(11):3002-5. doi: 10.1128/AAC.42.11.3002.
The susceptibilities of 49 isolates recovered from orthopedic implants to seven antimicrobial agents were evaluated by the broth microdilution method. Ciprofloxacin and vancomycin were more active than gentamicin, representing aminoglycosides which are routinely incorporated into bone cement, and also more active than the peroperative antimicrobial agents cefamandole and erythromycin. The use of ciprofloxacin and vancomycin in vivo, therefore, warrants further evaluation.
采用肉汤微量稀释法评估了从骨科植入物中分离出的49株菌株对七种抗菌药物的敏感性。环丙沙星和万古霉素比庆大霉素更具活性，庆大霉素是常规添加到骨水泥中的氨基糖苷类药物，且环丙沙星和万古霉素也比术中使用的抗菌药物头孢孟多和红霉素更具活性。因此，环丙沙星和万古霉素在体内的应用值得进一步评估。
