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J Clin Pathol. 1998 Jul;51(7):502-5. doi: 10.1136/jcp.51.7.502.
2
Simultaneous high-performance liquid chromatographic determination of salicylates in whole blood, plasma and isolated erythrocytes.同时高效液相色谱法测定全血、血浆和分离红细胞中的水杨酸盐。
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Salicylic acid sans aspirin in animals and man: persistence in fasting and biosynthesis from benzoic acid.动物和人体中不含阿司匹林的水杨酸：禁食时的持久性及由苯甲酸的生物合成
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Salicylic acid in the serum of subjects not taking aspirin. Comparison of salicylic acid concentrations in the serum of vegetarians, non-vegetarians, and patients taking low dose aspirin.未服用阿司匹林受试者血清中的水杨酸。素食者、非素食者以及服用低剂量阿司匹林患者血清中水杨酸浓度的比较。
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本文引用的文献

1
Suppression of human colorectal mucosal prostaglandins: determining the lowest effective aspirin dose.抑制人类结肠黏膜前列腺素：确定阿司匹林的最低有效剂量。
J Natl Cancer Inst. 1997 Aug 6;89(15):1152-60. doi: 10.1093/jnci/89.15.1152.
2
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.炎症、阿司匹林与看似健康男性的心血管疾病风险
N Engl J Med. 1997 Apr 3;336(14):973-9. doi: 10.1056/NEJM199704033361401.
3
Urinary salicylate excretion in subjects eating a variety of diets shows that amounts of bioavailable salicylates in foods are low.食用各种不同饮食的受试者的尿水杨酸盐排泄情况表明，食物中生物可利用水杨酸盐的含量较低。
Am J Clin Nutr. 1996 Nov;64(5):743-7. doi: 10.1093/ajcn/64.5.743.
4
Rapid high-performance liquid chromatographic assay for salicylic acid in plasma without solvent extraction.无需溶剂萃取的血浆中水杨酸快速高效液相色谱测定法。
J Chromatogr Sci. 1996 Apr;34(4):166-73. doi: 10.1093/chromsci/34.4.166.
5
Prostaglandin endoperoxide synthase: why two isoforms?前列腺素内过氧化物合酶：为何有两种同工型？
Am J Physiol. 1996 Mar;270(3 Pt 1):G393-400. doi: 10.1152/ajpgi.1996.270.3.G393.
6
Differential growth inhibition by the aspirin metabolite salicylate in human colorectal tumor cell lines: enhanced apoptosis in carcinoma and in vitro-transformed adenoma relative to adenoma relative to adenoma cell lines.
Cancer Res. 1996 May 15;56(10):2273-6.
7
Is aspirin a prodrug for antioxidant and cytokine-modulating oxymetabolites?阿司匹林是一种用于抗氧化和调节细胞因子的氧代代谢物的前体药物吗？
Agents Actions. 1993 May;39(1-2):49-58. doi: 10.1007/BF01975714.
8
Aspirin and the prevention of colorectal cancer: a review of the evidence.阿司匹林与结直肠癌的预防：证据综述
Semin Surg Oncol. 1994 May-Jun;10(3):158-64. doi: 10.1002/ssu.2980100303.
9
Direct gradient reversed-phase high-performance liquid chromatographic determination of salicylic acid, with the corresponding glycine and glucuronide conjugates in human plasma and urine.直接梯度反相高效液相色谱法测定人血浆和尿液中的水杨酸及其相应的甘氨酸和葡萄糖醛酸共轭物。
J Chromatogr. 1994 Feb 11;652(2):161-70. doi: 10.1016/0378-4347(93)e0381-y.
10
Take two glasses of wine and see me in the morning.喝两杯酒，明天早上再来找我。
Lancet. 1994 Jun 4;343(8910):1428-9. doi: 10.1016/s0140-6736(94)92550-x.

水杨酸酯作为血清正常成分的鉴定：饮食与健康之间的联系？

The identification of salicylates as normal constituents of serum: a link between diet and health?

作者信息

Paterson J R, Blacklock C, Campbell G, Wiles D, Lawrence J R

机构信息

Department of Biochemistry, Dumfries and Galloway Royal Infirmary, UK.

出版信息

J Clin Pathol. 1998 Jul;51(7):502-5. doi: 10.1136/jcp.51.7.502.

DOI:10.1136/jcp.51.7.502
PMID:9797725
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC500801/
Abstract

AIM

To examine sera for the presence of salicylic acid and 2,3- and 2,5-dihydroxybenzoic acids (2,3- and 2,5-DHBA), in individuals not taking salicylate drugs.

METHODS

Extracts of acidified serum samples were analysed by high performance liquid chromatography with electro-chemical detection. The chromatographic conditions were altered, and the retention times of the unknown compounds compared against authentic salicylic acid, 2,3-DHBA, and 2,5-DHBA. Serum samples (some spiked with salicylic acid) were incubated with salicylate hydroxylase and analyses undertaken. An extract of acidified serum was derivatised using N-methyl-N-trimethylsilyltrifluoroacetamide and the salicylic acid derivative identified by gas chromatography-mass spectrometry.

RESULTS

Salicylic acid, 2,3-DHBA, and 2,5-DHBA were identified as being normal constituents of serum.

CONCLUSIONS

Salicylic acid, 2,3-DHBA, and 2,5-DHBA possess anti-inflammatory properties. The finding that these compounds are present as normal constituents of serum, possibly arising from diet, raises important questions as to their role in the promotion of health.

摘要

目的

检测未服用水杨酸盐类药物个体的血清中水杨酸、2,3 - 二羟基苯甲酸和2,5 - 二羟基苯甲酸（2,3 - DHBA和2,5 - DHBA）的存在情况。

方法

采用高效液相色谱 - 电化学检测法分析酸化血清样本提取物。改变色谱条件，将未知化合物的保留时间与水杨酸、2,3 - DHBA和2,5 - DHBA标准品进行比较。血清样本（部分添加了水杨酸）与水杨酸羟化酶孵育后进行分析。酸化血清提取物用N - 甲基 - N - 三甲基硅烷基三氟乙酰胺衍生化，通过气相色谱 - 质谱法鉴定水杨酸衍生物。

结果

水杨酸、2,3 - DHBA和2,5 - DHBA被鉴定为血清的正常成分。

结论

水杨酸、2,3 - DHBA和2,5 - DHBA具有抗炎特性。这些化合物作为血清正常成分存在，可能源于饮食，这一发现引发了关于它们在促进健康方面作用的重要问题。