Wilhelm H, Lüdtke H, Wilhelm B
Department of Pathophysiology of Vision and Neuro-ophthalmology, University Eye Clinic, Tübingen, Germany.
Graefes Arch Clin Exp Ophthalmol. 1998 Oct;236(10):725-9. doi: 10.1007/s004170050149.
Pupillary oscillations in darkness are considered to be a sign of sleepiness. The purpose of this pilot study was to ascertain whether pupillary oscillations were more pronounced in patients with hypersomnia than in normals.
Seven patients (four with sleep apnea syndrome, three with narcolepsy) and seven age-matched controls underwent pupillography for 11 min in complete darkness. The changes in pupil size were analyzed mathematically to determine quantitatively the amount of pupillary instability.
Hypersomniacs had much higher amounts of pupillary oscillations in darkness than normals. The differences were significant. Baseline pupil size did not differ significantly between the two groups.
This study showed that a pupillographic sleepiness test based on the evaluation of spontaneous pupillary changes in darkness is applicable in hypersomniacs and may facilitate therapy control, i.e. diagnostic grading by measuring daytime sleepiness objectively.
黑暗中瞳孔振荡被认为是困倦的一种表现。这项初步研究的目的是确定瞳孔振荡在发作性睡病患者中是否比正常人更明显。
7名患者（4名患有睡眠呼吸暂停综合征，3名患有发作性睡病）和7名年龄匹配的对照者在完全黑暗中进行了11分钟的瞳孔描记术。对瞳孔大小的变化进行数学分析，以定量确定瞳孔不稳定的程度。
发作性睡病患者在黑暗中的瞳孔振荡比正常人多得多。差异具有显著性。两组之间的基线瞳孔大小没有显著差异。
本研究表明，基于评估黑暗中自发瞳孔变化的瞳孔描记困倦测试适用于发作性睡病患者，并且可能有助于治疗控制，即通过客观测量白天嗜睡程度进行诊断分级。
