Helfand R F, Kim D K, Gary H E, Edwards G L, Bisson G P, Papania M J, Heath J L, Schaff D L, Bellini W J, Redd S C, Anderson L J
Emory University, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Atlanta, Georgia, USA.
J Med Virol. 1998 Dec;56(4):337-41. doi: 10.1002/(sici)1096-9071(199812)56:4<337::aid-jmv9>3.0.co;2-3.
This study investigated the frequency of mild or asymptomatic measles infections among 44 persons exposed to a student with measles during a 3-day bus trip using two buses. Questionnaires and serum samples were obtained 26-37 days after the trip. All participants had detectable measles-neutralizing antibodies, and none developed classic measles symptoms. Ten persons (23%) were IgM positive for measles, indicating recent infection. Among previously vaccinated IgM-negative persons, those who rode on bus A with the index case-patient had significantly higher microneutralization titers than those on bus B (P= .001), suggesting that some persons on bus A were infected but were IgM negative at the time of the study. Mild or asymptomatic measles infections are probably very common among measles-immune persons exposed to measles cases and may be the most common manifestation of measles during outbreaks in highly immune populations.
本研究调查了在为期3天的巴士旅行中，44名接触过一名患麻疹学生的人员中轻度或无症状麻疹感染的频率。此次旅行使用了两辆巴士。在旅行结束26 - 37天后收集了调查问卷和血清样本。所有参与者均检测到麻疹中和抗体，且无人出现典型的麻疹症状。10人（23%）麻疹IgM呈阳性，表明近期感染。在之前接种过疫苗且IgM阴性的人员中，与首例病例同乘A巴士的人员，其微量中和抗体滴度显著高于乘坐B巴士的人员（P = .001），这表明A巴士上的一些人受到了感染，但在研究时IgM呈阴性。轻度或无症状麻疹感染在接触麻疹病例的有麻疹免疫力的人群中可能非常常见，并且可能是高免疫人群麻疹暴发期间最常见的表现形式。
