Adzhubei I A, Adzhubei A A
Department of Molecular Biology, Faculty of Biology, Lomonosov Moscow State University, 119899 Moscow, Russia.
Nucleic Acids Res. 1999 Jan 1;27(1):268-71. doi: 10.1093/nar/27.1.268.
Two more organisms from different taxonomic groups were added to a new version of the Integrated Sequence-Structure Database (ISSD). ISSD serves as an integrated source of sequence and structure information for the analysis of correlations between mRNA synonymous codon usage and three-dimensional structure of the encoded proteins. ISSD now holds 88 non-homologous Escherichia coli proteins and 25 yeast Saccharomyces cerevisiae proteins in addition to the expanded set of mammalian proteins, which includes 166 proteins (107 in ISSD Version 1.0). Comparison of ISSD sequences with organism-specific codon usage data derived from CUTG database shows that it is a representative subset of the GenBank coding sequences data. Preliminary results of the statistical analysis confirm that sequence-structure correlations observed by us earlier are also present in the upgraded ISSD (Version 2.0), including bacterial and yeast proteins. The ISSD Version 2.0 release includes an improved Web-based data search and retrieval system and is accessible via URL http://www.protein.bio.msu.su/issd/. ISSD can be also accessed at ExPASy, URL http://www.expasy.ch/swissmod/swiss-model.htm l
另外两种来自不同分类学组的生物体被添加到了综合序列-结构数据库（ISSD）的新版本中。ISSD作为序列和结构信息的综合来源，用于分析mRNA同义密码子使用与编码蛋白质三维结构之间的相关性。除了扩展的哺乳动物蛋白质集（包括166种蛋白质，ISSD 1.0版本中有107种）之外，ISSD现在还包含88种非同源的大肠杆菌蛋白质和25种酿酒酵母蛋白质。将ISSD序列与从CUTG数据库获得的特定生物体密码子使用数据进行比较表明，它是GenBank编码序列数据的一个代表性子集。统计分析的初步结果证实，我们之前观察到的序列-结构相关性在升级后的ISSD（2.0版本）中也存在，包括细菌和酵母蛋白质。ISSD 2.0版本发布包括一个改进的基于网络的数据搜索和检索系统，可通过网址http://www.protein.bio.msu.su/issd/访问。也可以在ExPASy上通过网址http://www.expasy.ch/swissmod/swiss-model.htm l访问ISSD
