气溶胶中塞姆利基森林病毒的灭活
Inactivation of Semliki Forest Virus in aerosols.
作者信息
de Jong J C, Harmsen M, Plantinga A D, Trouwbrost T
出版信息
Appl Environ Microbiol. 1976 Sep;32(3):315-9. doi: 10.1128/aem.32.3.315-319.1976.
Abstract
Purified Semliki forest virus in aerosols is inactivated rapidly at 40% and above 70% relative humidity. At all humidities tested the decay of virus infectivity runs parallel with the decrease in hemagglutination activity, whereas the biological integrity of the virus ribonucleic acid is preserved. Also, free infectious ribonucleic acid is stable after spraying at all relative humidities. Evidence is presented for the hypothesis that above 20% relative humidity, virus inactivation in aersols is mainly due to surface-dependent factors, damaging the virus coat.
摘要
气溶胶中的纯化塞姆利基森林病毒在相对湿度40%及70%以上时会迅速失活。在所有测试湿度下，病毒感染力的衰减与血凝活性的降低平行，而病毒核糖核酸的生物学完整性得以保留。此外，游离的感染性核糖核酸在所有相对湿度下喷雾后都很稳定。有证据支持这样的假说：相对湿度高于20%时，气溶胶中的病毒失活主要是由于表面相关因素破坏了病毒衣壳。
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