Peungvicha P, Thirawarapan S S, Watanabe H
Department of Physiology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
Jpn J Pharmacol. 1998 Nov;78(3):395-8. doi: 10.1254/jjp.78.395.
We studied the hypoglycemic effect of 4-hydroxybenzoic acid, a constituent of the root of Pandanus odorus Ridl. (Pandanaceae, Thai name: Toei-hom), in streptozotocin-diabetic rats. Oral administration of 4-hydroxybenzoic acid caused a decrease in plasma glucose levels dose-dependently in the diabetic rat. The constituent did not affect serum insulin level and liver glycogen content in the diabetic model, but increased glucose consumption in normal and diabetic rat diaphragms. These results suggest that 4-hydroxybenzoic acid produces a hypoglycemic effect mediated by an increase in the peripheral glucose consumption.
我们研究了露兜树（露兜树科，泰语名：Toei-hom）根中的一种成分4-羟基苯甲酸对链脲佐菌素诱导的糖尿病大鼠的降血糖作用。口服4-羟基苯甲酸可使糖尿病大鼠的血糖水平呈剂量依赖性降低。在糖尿病模型中，该成分不影响血清胰岛素水平和肝糖原含量，但可增加正常和糖尿病大鼠膈肌的葡萄糖消耗量。这些结果表明，4-羟基苯甲酸通过增加外周葡萄糖消耗介导产生降血糖作用。
