Ishida K, Yamamoto T, Kitazawa Y
Department of Ophthalmology, Gifu University School of Medicine, Japan.
J Glaucoma. 1998 Dec;7(6):372-7.
To investigate clinical factors associated with the progression of visual field loss in normal-tension glaucoma (NTG).
One hundred and ten patients with NTG whose cases were followed for more than 2 years were retrospectively analyzed with the Kaplan-Meier life table method and the Cox proportional hazards model. Several clinical factors were investigated to find a possible association with progression of glaucomatous visual field defined by two different definitions: one by mean deviation change and the other by pointwise comparison.
The Cox proportional hazards model indicated that change in the visual field was significantly associated with treatment with calcium channel blockers, recovery rate from a cold recovery test, systolic blood pressure, disc hemorrhage, corrected pattern standard deviation, mean deviation, and fluctuation of intraocular pressure (IOP) at a 24-hour phasing. The probability of nonprogression of visual field loss was significantly higher for patients taking calcium channel blockers than for control subjects by either definition of visual field progression.
Factors other than IOP, including the use of calcium channel blockers, are associated with the outcome of visual field loss in NTG.
研究与正常眼压性青光眼（NTG）视野缺损进展相关的临床因素。
采用Kaplan-Meier生存表法和Cox比例风险模型，对110例随访时间超过2年的NTG患者进行回顾性分析。研究了几个临床因素，以寻找与两种不同定义的青光眼视野进展可能存在的关联：一种是通过平均偏差变化定义，另一种是通过逐点比较定义。
Cox比例风险模型表明，视野变化与钙通道阻滞剂治疗、冷恢复试验的恢复率、收缩压、视盘出血、校正模式标准差、平均偏差以及24小时眼压波动显著相关。无论采用哪种视野进展定义，服用钙通道阻滞剂的患者视野缺损不进展的概率均显著高于对照组。
除眼压外，包括使用钙通道阻滞剂在内的其他因素与NTG患者视野缺损的结果相关。
