Ogundele M O
Department of Immunology, Georg-August University, Göttingen, Germany.
Mediators Inflamm. 1998;7(5):363-5. doi: 10.1080/09629359890893.
Lysozyme is an ubiquitous enzyme found in most biological secretions and leukocytes. This study was aimed at investigating its interaction with other inflammatory mediators on mucosa surfaces, particularly the complement system. Lysozyme has been shown in our present study, to inhibit the haemolytic activity of serum complement in a dose-dependent fashion, when tested within the levels present in normal and inflamed breast-milk samples, and other mucosal secretions. This represents a new anti-inflammatory action of lysozyme in relation to the serum complement, and the exact mode of the interaction need further studies.
溶菌酶是一种存在于大多数生物分泌物和白细胞中的普遍存在的酶。本研究旨在探讨其在黏膜表面与其他炎症介质的相互作用,特别是与补体系统的相互作用。在我们目前的研究中发现,当在正常和发炎母乳样本以及其他黏膜分泌物中的水平进行测试时,溶菌酶以剂量依赖的方式抑制血清补体的溶血活性。这代表了溶菌酶相对于血清补体的一种新的抗炎作用,其相互作用的确切方式需要进一步研究。