Radosavljevic M, Koenig H, Letscher-Bru V, Waller J, Maloisel F, Lioure B, Herbrecht R
Institut de Parasitologie et de Pathologie Tropicale, Faculté de Médecine, 67000 Strasbourg, France.
J Clin Microbiol. 1999 Feb;37(2):475-7. doi: 10.1128/JCM.37.2.475-477.1999.
We report the first case of fungemia due to Candida catenulata, a contaminant of dairy products. C. catenulata was isolated from three blood cultures of a patient with gastric cancer. The patient failed to respond to fluconazole but recovered after treatment was switched to amphotericin B. In vitro, C. catenulata was susceptible to amphotericin B and itraconazole and was also susceptible to fluconazole in dose-dependent manner. The likely portal of entry was the digestive tract, as the patient often ate cheese and had multiple gastric ulcerations.
我们报告了首例由乳制品污染物链状假丝酵母菌引起的真菌血症病例。链状假丝酵母菌从一名胃癌患者的三次血培养中分离得到。该患者对氟康唑治疗无反应，但在改用两性霉素B治疗后康复。体外实验中，链状假丝酵母菌对两性霉素B和伊曲康唑敏感，对氟康唑也呈剂量依赖性敏感。可能的感染途径是消化道，因为该患者经常食用奶酪且有多处胃溃疡。
