Magos L, Webb M
Arch Toxicol. 1976 Sep 15;36(1):63-9. doi: 10.1007/BF00277564.
Forty-eight hours after the simultaneous administration of either 1.8 mumoles Se (as Na2SeO3) to 200 g male rats with equivalent doses of Cd (as CdCl2) or 0.5 mumoles Se with equivalent doses of Hg (as HgCl2) the retention of selenium at the subcutaneous injection site was affected only when it was given in a single injection with the heavy metal. The retention of cadmium was increased only if selenium was injected separately and the retention of mercury was increased both in single and separate injections. When there was an increase in retention at the site of injection, this made up less than 8% of the dose for selenium and mercury and 3% for cadmium and thus could not explain either changes in distribution or the reported protective effects by one metal against the other. The shift in the distributionpattern of one metal caused by the other metal was similar, and independent of whether they were injected in single or separate injections. However the shift in the distribution of interacting metals showed some differences indicating that interaction could not be mediated through the formation of a stable complex between selenium on the one hand and mercury or cadmium on the other.
给200克雄性大鼠同时注射1.8微摩尔硒（以亚硒酸钠形式）和等量镉（以氯化镉形式）或0.5微摩尔硒和等量汞（以氯化汞形式）48小时后，仅当硒与重金属单次注射时，皮下注射部位的硒潴留才会受到影响。仅当硒单独注射时，镉的潴留量增加；而汞的潴留量在单次注射和单独注射时均增加。当注射部位的潴留量增加时，对于硒和汞而言，增加量占剂量的比例不到8%，对于镉而言则为3%，因此这既无法解释分布变化，也无法解释一种金属对另一种金属的报道保护作用。一种金属引起的另一种金属分布模式的变化是相似的，且与它们是单次注射还是单独注射无关。然而，相互作用金属的分布变化存在一些差异，表明这种相互作用无法通过硒与汞或镉之间形成稳定络合物来介导。
