Saltzman J R, Russell R M, Golner B, Barakat S, Dallal G E, Goldin B R
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University and the Tufts University School of Medicine, Boston, USA.
Am J Clin Nutr. 1999 Jan;69(1):140-6. doi: 10.1093/ajcn/69.1.140.
Lactose intolerance is the most common disorder of intestinal carbohydrate digestion. Lactobacillus acidophilus BG2FO4 is a strain of lactobacilli with properties of marked intestinal adherence and high beta-galactosidase activity.
This study was designed to determine whether oral feeding of Lactobacillus acidophilus BG2FO4 leads to a lactose-tolerant state.
We studied 42 subjects with self-reported lactose intolerance and performed breath-hydrogen tests to determine whether they were lactose maldigesters. Subjects with established lactose maldigestion (n = 24) were invited to be randomly assigned to an omeprazole-treated (hypochlorhydric) group or a non-omeprazole-treated group, but 6 subjects chose not to participate. All randomly assigned subjects (n = 18) ingested Lactobacillus acidophilus BG2FO4 twice per day for 7 d and stool samples were collected. Breath-hydrogen tests were performed and symptom scores were recorded at baseline and after lactobacilli ingestion.
Lactose maldigestion was established in 24 of 42 subjects (57%) with self-reported lactose intolerance. In 18 lactose-maldigesting subjects, overall hydrogen production and symptom scores after ingestion of Lactobacillus acidophilus BG2FO4 were not significantly different from baseline values. Live Lactobacillus acidophilus BG2FO4 was recovered in stool samples from 7 subjects.
Lactose intolerance is overreported in subjects with gastrointestinal symptoms after lactose ingestion. Treatment of lactose-maldigesting subjects with and without hypochlorhydria with Lactobacillus acidophilus BG2FO4 for 7 d failed to change breath-hydrogen excretion significantly after lactose ingestion.
乳糖不耐受是肠道碳水化合物消化最常见的病症。嗜酸乳杆菌BG2FO4是一种具有显著肠道黏附特性和高β-半乳糖苷酶活性的乳杆菌菌株。
本研究旨在确定口服嗜酸乳杆菌BG2FO4是否会导致乳糖耐受状态。
我们研究了42名自述有乳糖不耐受的受试者，并进行了呼气氢试验以确定他们是否为乳糖消化不良者。已确诊乳糖消化不良的受试者（n = 24）被邀请随机分配到奥美拉唑治疗（低胃酸）组或非奥美拉唑治疗组，但有6名受试者选择不参与。所有随机分配的受试者（n = 18）每天摄入嗜酸乳杆菌BG2FO4两次，共7天，并收集粪便样本。在基线和摄入乳杆菌后进行呼气氢试验并记录症状评分。
42名自述有乳糖不耐受的受试者中，有24名（57%）被确诊为乳糖消化不良。在18名乳糖消化不良的受试者中，摄入嗜酸乳杆菌BG2FO4后的总体产氢量和症状评分与基线值无显著差异。7名受试者的粪便样本中检测到活的嗜酸乳杆菌BG2FO4。
乳糖摄入后有胃肠道症状的受试者中，乳糖不耐受的报告存在过度情况。对有或无低胃酸的乳糖消化不良受试者用嗜酸乳杆菌BG2FO4治疗7天，未能显著改变乳糖摄入后的呼气氢排泄量。
