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Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes.通过在两个基因的表达之间进行切换来产生高等真核生物中的条件性突变体。
Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):1013-8. doi: 10.1073/pnas.96.3.1013.
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Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16.具有不同二聚化结构域的四环素调控因子可实现p16介导的可逆性生长抑制。
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Graded transcriptional response to different concentrations of a single transactivator.对单一反式激活因子不同浓度的分级转录反应。
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The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes.非洲爪蟾卵母细胞中全或无细胞命运转换的生化基础。
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Stepwise selection of TetR variants recognizing tet operator 6C with high affinity and specificity.逐步筛选出对四环素操纵子6C具有高亲和力和特异性的TetR变体。
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Stepwise selection of TetR variants recognizing tet operator 4C with high affinity and specificity.逐步筛选出对tet操纵子4C具有高亲和力和特异性的TetR变体。
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Determinants of protein-protein recognition by four helix bundles: changing the dimerization specificity of Tet repressor.四螺旋束介导的蛋白质-蛋白质识别的决定因素：改变Tet阻遏物的二聚化特异性
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High-efficiency retroviral infection of primary myoblasts.原代成肌细胞的高效逆转录病毒感染
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Versatile retrovirus vector systems for regulated gene expression in vitro and in vivo.用于体外和体内调控基因表达的多功能逆转录病毒载体系统。
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Tet B or not tet B: advances in tetracycline-inducible gene expression.

作者信息

Blau H M, Rossi F M

机构信息

Department of Molecular Pharmacology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5332, USA.

出版信息

Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):797-9. doi: 10.1073/pnas.96.3.797.

DOI:10.1073/pnas.96.3.797
PMID:9927646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC33520/
Abstract
摘要