血浆中血栓素A2样物质的持续存在及血小板释放诱导活性
Persistence of thromboxane A2-like material and platelet release-inducing activity in plasma.
作者信息
Smith J B, Ingerman C, Silver M J
出版信息
J Clin Invest. 1976 Nov;58(5):1119-22. doi: 10.1172/JCI108564.
Abstract
During the incubation of arachidonic acid with platelet-rich plasma, a persistent activity appeared that caused the release of [14C]5-hydroxytryptamine from indomethacin-treated platelets. By the time-course of its appearance and disappearance, this release-inducing activity could be dissociated from prostaglandin endoperoxides and associated with thromboxane A2-like material. This material persists in plasma because of its continued production and increased stability.
摘要
在花生四烯酸与富血小板血浆孵育期间，出现了一种持续的活性，该活性导致吲哚美辛处理过的血小板释放[14C]5-羟色胺。根据其出现和消失的时间进程，这种释放诱导活性可与前列腺素内过氧化物分离，并与血栓素A2样物质相关。由于这种物质持续产生且稳定性增加，它在血浆中持续存在。
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本文引用的文献
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Physiological role of an endoperoxide in human platelets: hemostatic defect due to platelet cyclo-oxygenase deficiency.内过氧化物在人血小板中的生理作用：血小板环氧化酶缺乏导致的止血缺陷。
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