血浆中血栓素A2样物质的持续存在及血小板释放诱导活性
Persistence of thromboxane A2-like material and platelet release-inducing activity in plasma.
作者信息
Smith J B, Ingerman C, Silver M J
出版信息
J Clin Invest. 1976 Nov;58(5):1119-22. doi: 10.1172/JCI108564.
Abstract
During the incubation of arachidonic acid with platelet-rich plasma, a persistent activity appeared that caused the release of [14C]5-hydroxytryptamine from indomethacin-treated platelets. By the time-course of its appearance and disappearance, this release-inducing activity could be dissociated from prostaglandin endoperoxides and associated with thromboxane A2-like material. This material persists in plasma because of its continued production and increased stability.
摘要
在花生四烯酸与富血小板血浆孵育期间，出现了一种持续的活性，该活性导致吲哚美辛处理过的血小板释放[14C]5-羟色胺。根据其出现和消失的时间进程，这种释放诱导活性可与前列腺素内过氧化物分离，并与血栓素A2样物质相关。由于这种物质持续产生且稳定性增加，它在血浆中持续存在。
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本文引用的文献
1
2
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J Clin Invest. 1974 May;53(5):1468-72. doi: 10.1172/JCI107695.
3
Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation.两种引起血小板聚集的前列腺素内过氧化物的分离与结构
Proc Natl Acad Sci U S A. 1974 Feb;71(2):345-9. doi: 10.1073/pnas.71.2.345.
4
Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets.前列腺素内过氧化物。人血小板中花生四烯酸的新转化。
Proc Natl Acad Sci U S A. 1974 Sep;71(9):3400-4. doi: 10.1073/pnas.71.9.3400.
5
Arachidonic acid-induced human platelet aggregation and prostaglandin formation.花生四烯酸诱导的人血小板聚集和前列腺素形成。
Prostaglandins. 1973 Dec;4(6):863-75. doi: 10.1016/0090-6980(73)90121-4.
6
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7
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8
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