Zaczek A, Zetterström C
St. Erik's Eye Hospital, Karolinska Institute, Stockholm, Sweden.
J Cataract Refract Surg. 1999 Feb;25(2):233-7. doi: 10.1016/s0886-3350(99)80132-1.
To compare posterior capsule opacification (PCO) after phacoemulsification and implantation of heparin-surface-modified (HSM) poly(methyl methacrylate) (PMMA) intraocular lenses (IOLs) in the capsular bag in patients with diabetes mellitus with that in a control group.
St. Erik's Eye Hospital, Stockholm, Sweden.
This prospective study comprised 26 patients with diabetes mellitus and 26 control patients without diabetes. Those with glaucoma, exfoliation syndrome, uveitis, and pupil size smaller than 6.0 mm after dilation were excluded. All patients received the same standardized phacoemulsification procedure with implantation of an HSM PMMA IOL in the capsular bag. Posterior capsule opacification was scored 1 and 2 years after surgery by evaluating retroillumination images taken with a Scheimpflug camera (Nidek Anterior Eye Segment Analysis System) after pupil dilation with phenylephrine 10% and cyclopentolate 1%. The PCO density behind the IOL optic was graded clinically from 0 to 4 (0 = none, 1 = minimal, 2 = mild, 3 = moderate, 4 = severe) and scored using the Evaluation of Posterior Capsule Opacification medical software developing system.
No differences in PCO were found between the diabetic and control groups 1 year after surgery. The total PCO score was significantly less in diabetic than in control eyes 2 years after surgery (P < .05, Mann-Whitney). In addition, progression of PCO from 1 year to 2 years after surgery was significantly less in diabetic groups with different stages of diabetic retinopathy than in the control group (P < or = .05, Kruskal-Wallis analysis of variance and multiple comparisons).
The rate of PCO after phacoemulsification was statistically significantly lower in patients with diabetes mellitus than in those without diabetes.
比较糖尿病患者行超声乳化白内障吸除术并植入肝素表面修饰（HSM）的聚甲基丙烯酸甲酯（PMMA）人工晶状体（IOL）后囊膜混浊（PCO）情况与对照组的差异。
瑞典斯德哥尔摩圣埃里克眼科医院。
这项前瞻性研究纳入了26例糖尿病患者和26例非糖尿病对照患者。排除患有青光眼、剥脱综合征、葡萄膜炎以及散瞳后瞳孔直径小于6.0mm的患者。所有患者均接受相同的标准化超声乳化白内障吸除术，并在囊袋内植入HSM PMMA IOL。术后1年和2年，通过评估使用Nidek眼前节分析系统的Scheimpflug相机在使用10%去氧肾上腺素和1%环喷托酯散瞳后拍摄的后照光图像来对后囊膜混浊进行评分。IOL光学部后方的PCO密度按临床分级为0至4级（0级=无，1级=轻度，2级=中度，3级=重度，4级=极重度），并使用后囊膜混浊评估医学软件开发系统进行评分。
术后1年，糖尿病组和对照组之间的PCO无差异。术后2年，糖尿病组的总PCO评分显著低于对照组（P<.05，Mann-Whitney检验）。此外，不同糖尿病视网膜病变阶段的糖尿病组术后1年至2年PCO的进展明显低于对照组（P≤.05，Kruskal-Wallis方差分析和多重比较）。
糖尿病患者超声乳化白内障吸除术后PCO发生率在统计学上显著低于非糖尿病患者。
