Goldstein J A, Reller L B, Wang W L
Am J Clin Pathol. 1976 Dec;66(6):1012-5. doi: 10.1093/ajcp/66.6.1012.
The limulus amebocyte lysate test for endotoxin was done on samples of blood from 22 well babies and 33 neonates in an intensive-care nursery. The objective was to determine whether falsely positive test results occurred in samples from newborn infants during acquisition of usual bowel flora. One neonate had a transiently positive limulus amebocyte lysate test; he had clinical signs of spesis, but no bacteremia could be documented. Unlike the nitroblue tetrazolium test, the limulus amebocyte lysate test does not appear to be regularly positive in neonates. The sensitivity of the test in detection of endotoxemia associated with gram-negative spesis in the neonate remains to be determined in a large prospective study.
对重症监护病房中22名健康婴儿和33名新生儿的血样进行了内毒素鲎试剂检测。目的是确定在新生儿获得正常肠道菌群期间，其样本中是否会出现假阳性检测结果。一名新生儿鲎试剂检测呈短暂阳性；他有败血症的临床症状，但未记录到菌血症。与硝基蓝四氮唑试验不同，鲎试剂检测在新生儿中似乎并非经常呈阳性。该检测在检测新生儿革兰氏阴性败血症相关内毒素血症中的敏感性仍有待大型前瞻性研究来确定。
