大肠杆菌外膜蛋白TolC参与肽抗生素微菌素J25的产生。
Escherichia coli outer membrane protein TolC is involved in production of the peptide antibiotic microcin J25.
作者信息
Delgado M A, Solbiati J O, Chiuchiolo M J, Farías R N, Salomón R A
机构信息
Departamento de Bioquímica de la Nutrición, INSIBIO Chacabuco 461, 4000 San Miguel de Tucumán, Argentina.
出版信息
J Bacteriol. 1999 Mar;181(6):1968-70. doi: 10.1128/JB.181.6.1968-1970.1999.
Abstract
A Tn5 insertion in tolC eliminated microcin J25 production. The mutation had little effect on the expression of the microcin structural gene and presumably acted by blocking microcin secretion. The tolC mutants carrying multiple copies of the microcin genes were less immune to the microcin. TolC is thus likely a component of a microcin export complex containing the McjD immunity protein, an ABC exporter.
摘要
Tn5插入tolC基因导致微菌素J25的产生被消除。该突变对微菌素结构基因的表达影响很小，推测其作用是通过阻断微菌素的分泌。携带多个微菌素基因拷贝的tolC突变体对微菌素的免疫性较低。因此，TolC可能是包含McjD免疫蛋白（一种ABC转运蛋白）的微菌素输出复合体的一个组成部分。
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