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本文引用的文献

1
Prevalence of a putative efflux mechanism among fluoroquinolone-resistant clinical isolates of Streptococcus pneumoniae.肺炎链球菌耐氟喹诺酮临床分离株中一种假定外排机制的流行情况。
Antimicrob Agents Chemother. 1998 Aug;42(8):2032-5. doi: 10.1128/AAC.42.8.2032.
2
The effect of reserpine, an inhibitor of multi-drug efflux pumps, on the in-vitro susceptibilities of fluoroquinolone-resistant strains of Streptococcus pneumoniae to norfloxacin.利血平（一种多药外排泵抑制剂）对耐氟喹诺酮类肺炎链球菌菌株体外对诺氟沙星敏感性的影响。
J Antimicrob Chemother. 1997 Sep;40(3):458-60. doi: 10.1093/jac/40.3.458.
3
Active efflux as a mechanism of resistance to ciprofloxacin in Streptococcus pneumoniae.主动外排作为肺炎链球菌对环丙沙星耐药的一种机制。
Antimicrob Agents Chemother. 1997 Sep;41(9):1973-8. doi: 10.1128/AAC.41.9.1973.
4
Apparent involvement of a multidrug transporter in the fluoroquinolone resistance of Streptococcus pneumoniae.多药转运蛋白明显参与肺炎链球菌对氟喹诺酮类药物的耐药性。
Antimicrob Agents Chemother. 1997 Jun;41(6):1396-8. doi: 10.1128/AAC.41.6.1396.
5
Inhibition of the multidrug transporter NorA prevents emergence of norfloxacin resistance in Staphylococcus aureus.多药转运蛋白NorA的抑制可防止金黄色葡萄球菌中诺氟沙星耐药性的出现。
Antimicrob Agents Chemother. 1996 Nov;40(11):2673-4. doi: 10.1128/AAC.40.11.2673.
6
ParC subunit of DNA topoisomerase IV of Streptococcus pneumoniae is a primary target of fluoroquinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype.肺炎链球菌DNA拓扑异构酶IV的ParC亚基是氟喹诺酮类药物的主要作用靶点，并与DNA回旋酶A亚基协同形成耐药表型。
Antimicrob Agents Chemother. 1996 Oct;40(10):2252-7. doi: 10.1128/AAC.40.10.2252.
7
Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1.由人类多药转运蛋白MDR1的细菌同源物介导的多药耐药性。
Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10668-72. doi: 10.1073/pnas.93.20.10668.
8
Inducible NorA-mediated multidrug resistance in Staphylococcus aureus.金黄色葡萄球菌中诱导型NorA介导的多重耐药性。
Antimicrob Agents Chemother. 1995 Dec;39(12):2650-5. doi: 10.1128/AAC.39.12.2650.
9
Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium smegmatis.质子反向转运体家族的外排泵赋予耻垢分枝杆菌低水平氟喹诺酮耐药性。
Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):362-6. doi: 10.1073/pnas.93.1.362.
10
Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated.枯草芽孢杆菌的两种高度相似的多药转运蛋白，其表达受到差异调节。
J Bacteriol. 1995 Jul;177(14):3904-10. doi: 10.1128/jb.177.14.3904-3910.1995.

多药外排抑制剂利血平对肺炎链球菌环丙沙星耐药性产生的抑制作用

Inhibition of the emergence of ciprofloxacin resistance in Streptococcus pneumoniae by the multidrug efflux inhibitor reserpine.

作者信息

Markham P N

机构信息

Influx, Inc., Chicago, Illinois 60612, USA.

出版信息

Antimicrob Agents Chemother. 1999 Apr;43(4):988-9. doi: 10.1128/AAC.43.4.988.

DOI:10.1128/AAC.43.4.988
PMID:10103220
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC89246/
Abstract

Recent evidence supports the contribution of a multidrug efflux mechanism to fluoroquinolone resistance in Streptococcus pneumoniae. In this paper I show that reserpine, an inhibitor of multidrug transporters in gram-positive bacteria, dramatically suppresses the in vitro emergence of ciprofloxacin-resistant variants of S. pneumoniae, suggesting that the combination of a fluoroquinolone with an inhibitor of multidrug transport may help preserve the efficacy of this class of antibiotics.

摘要

最近的证据支持多药外排机制在肺炎链球菌对氟喹诺酮类耐药中的作用。在本文中，我表明利血平，一种革兰氏阳性菌多药转运体的抑制剂，能显著抑制肺炎链球菌环丙沙星耐药变体的体外出现，这表明氟喹诺酮类药物与多药转运抑制剂联合使用可能有助于保持这类抗生素的疗效。