多药外排抑制剂利血平对肺炎链球菌环丙沙星耐药性产生的抑制作用
Inhibition of the emergence of ciprofloxacin resistance in Streptococcus pneumoniae by the multidrug efflux inhibitor reserpine.
作者信息
Markham P N
机构信息
Influx, Inc., Chicago, Illinois 60612, USA.
出版信息
Antimicrob Agents Chemother. 1999 Apr;43(4):988-9. doi: 10.1128/AAC.43.4.988.
Abstract
Recent evidence supports the contribution of a multidrug efflux mechanism to fluoroquinolone resistance in Streptococcus pneumoniae. In this paper I show that reserpine, an inhibitor of multidrug transporters in gram-positive bacteria, dramatically suppresses the in vitro emergence of ciprofloxacin-resistant variants of S. pneumoniae, suggesting that the combination of a fluoroquinolone with an inhibitor of multidrug transport may help preserve the efficacy of this class of antibiotics.
摘要
最近的证据支持多药外排机制在肺炎链球菌对氟喹诺酮类耐药中的作用。在本文中，我表明利血平，一种革兰氏阳性菌多药转运体的抑制剂，能显著抑制肺炎链球菌环丙沙星耐药变体的体外出现，这表明氟喹诺酮类药物与多药转运抑制剂联合使用可能有助于保持这类抗生素的疗效。
相似文献
1
Inhibition of the emergence of ciprofloxacin resistance in Streptococcus pneumoniae by the multidrug efflux inhibitor reserpine.多药外排抑制剂利血平对肺炎链球菌环丙沙星耐药性产生的抑制作用
Antimicrob Agents Chemother. 1999 Apr;43(4):988-9. doi: 10.1128/AAC.43.4.988.
2
In vitro infection model characterizing the effect of efflux pump inhibition on prevention of resistance to levofloxacin and ciprofloxacin in Streptococcus pneumoniae.体外感染模型，用于表征外排泵抑制对预防肺炎链球菌对左氧氟沙星和环丙沙星耐药性的影响。
Antimicrob Agents Chemother. 2007 Nov;51(11):3988-4000. doi: 10.1128/AAC.00391-07. Epub 2007 Sep 10.
3
Apparent involvement of a multidrug transporter in the fluoroquinolone resistance of Streptococcus pneumoniae.多药转运蛋白明显参与肺炎链球菌对氟喹诺酮类药物的耐药性。
Antimicrob Agents Chemother. 1997 Jun;41(6):1396-8. doi: 10.1128/AAC.41.6.1396.
4
Involvement of the putative ATP-dependent efflux proteins PatA and PatB in fluoroquinolone resistance of a multidrug-resistant mutant of Streptococcus pneumoniae.假定的ATP依赖性外排蛋白PatA和PatB参与肺炎链球菌多重耐药突变体对氟喹诺酮的耐药性
Antimicrob Agents Chemother. 2006 Feb;50(2):685-93. doi: 10.1128/AAC.50.2.685-693.2006.
5
Multiple novel inhibitors of the NorA multidrug transporter of Staphylococcus aureus.金黄色葡萄球菌NorA多药转运蛋白的多种新型抑制剂
Antimicrob Agents Chemother. 1999 Oct;43(10):2404-8. doi: 10.1128/AAC.43.10.2404.
6
Expression of efflux pump gene pmrA in fluoroquinolone-resistant and -susceptible clinical isolates of Streptococcus pneumoniae.肺炎链球菌氟喹诺酮耐药及敏感临床分离株中外排泵基因pmrA的表达
Antimicrob Agents Chemother. 2002 Mar;46(3):808-12. doi: 10.1128/AAC.46.3.808-812.2002.
7
The effect of reserpine, an inhibitor of multi-drug efflux pumps, on the in-vitro susceptibilities of fluoroquinolone-resistant strains of Streptococcus pneumoniae to norfloxacin.利血平（一种多药外排泵抑制剂）对耐氟喹诺酮类肺炎链球菌菌株体外对诺氟沙星敏感性的影响。
J Antimicrob Chemother. 1997 Sep;40(3):458-60. doi: 10.1093/jac/40.3.458.
8
The efflux pump inhibitor reserpine selects multidrug-resistant Streptococcus pneumoniae strains that overexpress the ABC transporters PatA and PatB.外排泵抑制剂利血平可筛选出过度表达ABC转运蛋白PatA和PatB的多重耐药肺炎链球菌菌株。
Antimicrob Agents Chemother. 2008 May;52(5):1677-85. doi: 10.1128/AAC.01644-07. Epub 2008 Mar 24.
9
In vitro activity of older and newer fluoroquinolones against efflux-mediated high-level ciprofloxacin-resistant Streptococcus pneumoniae.新旧氟喹诺酮类药物对由外排介导的高水平环丙沙星耐药肺炎链球菌的体外活性。
Int J Antimicrob Agents. 2004 Aug;24(2):185-7. doi: 10.1016/j.ijantimicag.2004.01.012.
10
Prevalence of a putative efflux mechanism among fluoroquinolone-resistant clinical isolates of Streptococcus pneumoniae.肺炎链球菌耐氟喹诺酮临床分离株中一种假定外排机制的流行情况。
Antimicrob Agents Chemother. 1998 Aug;42(8):2032-5. doi: 10.1128/AAC.42.8.2032.
引用本文的文献
1
Small-molecule strategies to combat antibiotic resistance: mechanisms, modifications, and contemporary approaches.对抗抗生素耐药性的小分子策略：作用机制、修饰及当代方法
RSC Adv. 2025 Jul 14;15(30):24450-24474. doi: 10.1039/d5ra04047g. eCollection 2025 Jul 10.
2
C-1 Substituted isoquinolines potentiate the antimycobacterial activity of rifampicin and ethambutol.C-1位取代的异喹啉增强利福平和乙胺丁醇的抗分枝杆菌活性。
Front Antibiot. 2023 May 9;2:1095013. doi: 10.3389/frabi.2023.1095013. eCollection 2023.
3
Serotype replacement and an increase in non-encapsulated isolates among community-acquired infections of during post-vaccine era in Japan.日本疫苗接种后时代社区获得性感染中血清型替换及非包膜分离株增加。
IJID Reg. 2023 Jul 15;8:105-110. doi: 10.1016/j.ijregi.2023.07.002. eCollection 2023 Sep.
4
Chemical composition of Kunth essential oil and evaluation of its antimicrobial and modulatory effects on antibiotic resistance, antibiofilm, and cell dimorphism inhibitory activities.昆斯精油的化学成分及其对抗生素耐药性、抗生物膜和细胞二态性抑制活性的抗菌及调节作用评估。
3 Biotech. 2023 Jul;13(7):255. doi: 10.1007/s13205-023-03681-1. Epub 2023 Jun 29.
5
Biological Potential of the Main Component, Thymoquinone, of in Pulp Therapy-In Vitro Study.百里醌的主要成分在牙髓治疗中的生物学潜力——体外研究
Life (Basel). 2022 Sep 15;12(9):1434. doi: 10.3390/life12091434.
6
Developing synergistic drug combinations to restore antibiotic sensitivity in drug-resistant .开发协同药物组合以恢复耐药菌对抗生素的敏感性。
Antimicrob Agents Chemother. 2023 May 1;65(5). doi: 10.1128/AAC.02554-20. Epub 2021 Feb 22.
7
Ligand Promiscuity between the Efflux Pumps Human P-Glycoprotein and S. aureus NorA.人源外排泵P-糖蛋白与金黄色葡萄球菌NorA之间的配体混杂性
ACS Med Chem Lett. 2012 Jan 23;3(3):248-51. doi: 10.1021/ml200293c. eCollection 2012 Mar 8.
8
Prevalence and antimicrobial resistance of Enterococcus species: a hospital-based study in China.肠球菌属的患病率及抗菌药物耐药性：一项在中国医院开展的研究
Int J Environ Res Public Health. 2014 Mar 21;11(3):3424-42. doi: 10.3390/ijerph110303424.
9
Antibacterial and resistance-modifying activities of thymoquinone against oral pathogens.百里醌对口腔病原体的抗菌和耐药修饰活性。
Ann Clin Microbiol Antimicrob. 2011 Jun 27;10:29. doi: 10.1186/1476-0711-10-29.
10
Synergy-directed fractionation of botanical medicines: a case study with goldenseal (Hydrastis canadensis).协同导向的草药分馏：以白毛茛（Hydrastis canadensis）为例。
J Nat Prod. 2011 Jul 22;74(7):1621-9. doi: 10.1021/np200336g. Epub 2011 Jun 10.
本文引用的文献
1
Prevalence of a putative efflux mechanism among fluoroquinolone-resistant clinical isolates of Streptococcus pneumoniae.肺炎链球菌耐氟喹诺酮临床分离株中一种假定外排机制的流行情况。
Antimicrob Agents Chemother. 1998 Aug;42(8):2032-5. doi: 10.1128/AAC.42.8.2032.
2
The effect of reserpine, an inhibitor of multi-drug efflux pumps, on the in-vitro susceptibilities of fluoroquinolone-resistant strains of Streptococcus pneumoniae to norfloxacin.利血平（一种多药外排泵抑制剂）对耐氟喹诺酮类肺炎链球菌菌株体外对诺氟沙星敏感性的影响。
J Antimicrob Chemother. 1997 Sep;40(3):458-60. doi: 10.1093/jac/40.3.458.
3
Active efflux as a mechanism of resistance to ciprofloxacin in Streptococcus pneumoniae.主动外排作为肺炎链球菌对环丙沙星耐药的一种机制。
Antimicrob Agents Chemother. 1997 Sep;41(9):1973-8. doi: 10.1128/AAC.41.9.1973.
4
Apparent involvement of a multidrug transporter in the fluoroquinolone resistance of Streptococcus pneumoniae.多药转运蛋白明显参与肺炎链球菌对氟喹诺酮类药物的耐药性。
Antimicrob Agents Chemother. 1997 Jun;41(6):1396-8. doi: 10.1128/AAC.41.6.1396.
5
Inhibition of the multidrug transporter NorA prevents emergence of norfloxacin resistance in Staphylococcus aureus.多药转运蛋白NorA的抑制可防止金黄色葡萄球菌中诺氟沙星耐药性的出现。
Antimicrob Agents Chemother. 1996 Nov;40(11):2673-4. doi: 10.1128/AAC.40.11.2673.
6
ParC subunit of DNA topoisomerase IV of Streptococcus pneumoniae is a primary target of fluoroquinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype.肺炎链球菌DNA拓扑异构酶IV的ParC亚基是氟喹诺酮类药物的主要作用靶点，并与DNA回旋酶A亚基协同形成耐药表型。
Antimicrob Agents Chemother. 1996 Oct;40(10):2252-7. doi: 10.1128/AAC.40.10.2252.
7
Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1.由人类多药转运蛋白MDR1的细菌同源物介导的多药耐药性。
Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10668-72. doi: 10.1073/pnas.93.20.10668.
8
Inducible NorA-mediated multidrug resistance in Staphylococcus aureus.金黄色葡萄球菌中诱导型NorA介导的多重耐药性。
Antimicrob Agents Chemother. 1995 Dec;39(12):2650-5. doi: 10.1128/AAC.39.12.2650.
9
Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium smegmatis.质子反向转运体家族的外排泵赋予耻垢分枝杆菌低水平氟喹诺酮耐药性。
Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):362-6. doi: 10.1073/pnas.93.1.362.
10
Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated.枯草芽孢杆菌的两种高度相似的多药转运蛋白，其表达受到差异调节。
J Bacteriol. 1995 Jul;177(14):3904-10. doi: 10.1128/jb.177.14.3904-3910.1995.
Zotero 插件