Hirakawa H, Iijima H, Gohdo T, Imai M, Tsukahara S
Department of Ophthalmology, Yamanashi Medical University, Tamaho, Japan.
Am J Ophthalmol. 1999 Apr;127(4):436-42. doi: 10.1016/s0002-9394(98)00408-5.
To determine the progression of defects in the central 10-degree visual field in patients with retinitis pigmentosa and choroideremia by means of univariate linear regression with respect to the mean deviation.
In a retrospective study, results of automated static perimetry in the central 10-degree visual field were reviewed for patients with retinitis pigmentosa and choroideremia. Univariate linear regression of mean deviation was undertaken for each eye that had field data from at least five tests in addition to the prior static perimetric experience during a period of 3.5 years or more. Data from 30 eyes of 16 patients fulfilled eligibility requirements; the mean number of fields was 5.8 (range, five to 10) and the mean follow-up period was 64 months (range, 42 to 97 months). Eyes were classified as progressive if the regression coefficient was negative and significantly different from zero, with a P value of less than .05.
Among 14 patients in whom both eyes were eligible for univariate linear regression analysis, a statistically significant progression was demonstrated in both eyes in four patients, only in one eye in five patients, and in neither eye in five patients. One of two patients, in whom only one eye was eligible for the study, showed significant progression in the eye. Overall, 14 (47%) of 30 eyes showed statistically significant progression with respect to the mean deviation. No eye showed significant improvement.
Automated static perimetry of the central 10-degree visual field measured approximately once or twice a year demonstrated the progressive nature of the disease with the use of univariate linear regression of mean deviation in 47% of eyes with retinitis pigmentosa and choroideremia during the follow-up period of 3.5 years or more. These results may be useful in understanding the clinical course of the diseases and counseling patients.
通过关于平均偏差的单变量线性回归，确定色素性视网膜炎和脉络膜血症患者中央10度视野缺损的进展情况。
在一项回顾性研究中，对色素性视网膜炎和脉络膜血症患者中央10度视野的自动静态视野检查结果进行了回顾。对每只眼睛进行平均偏差的单变量线性回归分析，这些眼睛除了在3.5年或更长时间内有先前的静态视野检查经验外，还至少有来自五次检查的视野数据。16名患者的30只眼睛的数据符合入选标准；平均视野检查次数为5.8次（范围为5至10次），平均随访期为64个月（范围为42至97个月）。如果回归系数为负且与零有显著差异（P值小于0.05），则将眼睛分类为进展性。
在双眼都符合单变量线性回归分析条件的14名患者中，4名患者的双眼均显示出统计学上的显著进展，5名患者仅一只眼睛有进展，5名患者的双眼均无进展。在仅一只眼睛符合研究条件的两名患者中，有一名患者的眼睛显示出显著进展。总体而言，30只眼睛中有14只（47%）在平均偏差方面显示出统计学上的显著进展。没有眼睛显示出显著改善。
在3.5年或更长时间的随访期内，每年大约进行一到两次测量的中央10度视野自动静态视野检查，通过平均偏差的单变量线性回归，证明了色素性视网膜炎和脉络膜血症47%的眼睛中疾病的进展性质。这些结果可能有助于理解疾病的临床过程并为患者提供咨询。
