Department of Ophthalmology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan,
Jpn J Ophthalmol. 2013 Nov;57(6):563-7. doi: 10.1007/s10384-013-0271-7. Epub 2013 Aug 23.
To investigate the various perimetric parameters that best predict reduction of best-corrected visual acuity (BCVA) to worse than 0.5 in the near future in eyes with retinitis pigmentosa (RP).
The most recent records obtained by Humphrey Field Analyzer (HFA) central 10-2 perimetry were studied for the right eyes of 123 patients (60 men and 63 women) with typical RP. The correlation between various parameters of perimetric sensitivity and BCVA was retrospectively studied. The receiver operating characteristic (ROC) curves were used to find the best parameter to discriminate eyes with BCVA ≥0.5 from those with BCVA <0.5.
Spearman rank correlation coefficients with logMAR BCVA were the highest for the foveal threshold (FT) and mean sensitivity of the test points within 1.4° of the fixation point (MS1.4). The ROC curve analysis revealed that the area under the curve was the largest for the MS1.4 among all the perimetric parameters for discriminating eyes with BCVA ≥0.5 from those with BCVA <0.5. The cutoff value of 30 dB showed 100 % specificity and 57 % sensitivity.
The risk of vision decreasing below 0.5 in the near future may be predicted when the mean sensitivity within 1.4° of the fixation point in the HFA 10-2 reaches 30 dB in eyes with RP.
探讨色素性视网膜炎（RP）患者中哪些周边视野参数最能预测近期最佳矫正视力（BCVA）下降至 0.5 以下。
对 123 例（60 名男性和 63 名女性）典型 RP 患者的右眼进行了 Humphrey 视野分析仪（HFA）中央 10-2 周边视野的最新记录研究。回顾性研究了周边视野敏感度的各种参数与 BCVA 之间的相关性。使用受试者工作特征（ROC）曲线来寻找最佳参数，以区分 BCVA≥0.5 的眼睛和 BCVA<0.5 的眼睛。
Spearman 秩相关系数与 logMAR BCVA 的相关性最高的是黄斑阈值（FT）和注视点 1.4°范围内的测试点平均敏感度（MS1.4）。ROC 曲线分析显示，在所有周边视野参数中，MS1.4 区分 BCVA≥0.5 的眼睛和 BCVA<0.5 的眼睛的曲线下面积最大。当 HFA 10-2 中注视点 1.4°范围内的平均敏感度达到 30dB 时，截断值为 100%特异性和 57%敏感性。
当 HFA 10-2 中注视点 1.4°范围内的平均敏感度达到 30dB 时，可能会预测 RP 患者的视力在近期内下降至 0.5 以下的风险。
